Neurological outcomes and associated perinatal factors in infants born between 22 and 25 weeks with active care.

作者信息

Ariyoshi Yu, Iriyama Takayuki, Seyama Takahiro, Sayama Seisuke, Yano Eriko, Suzuki Kensuke, Samejima Taiki, Ichinose Mari, Toshimitsu Masatake, Sone Kenbun, Ito Atsushi, Shitara Yoshihiko, Kumasawa Keiichi, Kashima Kohei, Kakiuchi Satsuki, Hirota Yasushi, Takahashi Naoto, Osuga Yutaka

机构信息

Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Department of Pediatrics, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

出版信息

J Perinatol. 2025 Feb;45(2):186-193. doi: 10.1038/s41372-024-02093-0. Epub 2024 Sep 18.

DOI:10.1038/s41372-024-02093-0

PMID:39294298

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11825359/

Abstract

OBJECTIVES

To elucidate the outcomes of periviable infants receiving active care (AC) and explore perinatal factors associated with neurodevelopmental outcomes.

METHODS

This is a single-center retrospective study on infants born at 22-25 weeks of gestation, all of whom received AC. A developmental quotient (DQ) ≥ 85 at corrected 18 months was judged as normal.

RESULTS

Fifty-seven infants were included in the study. The survival rates at discharge were 83%, 86%, 93%, and 93% at 22, 23, 24, and 25 gestational weeks, respectively. The overall percentage of normal DQ was 26/47 (55%). Acidemia in the arterial blood gas measured within 6 h after birth was identified as a factor significantly associated with subnormal DQ.

CONCLUSIONS

Not only high survival rates, but also favorable neurodevelopmental outcomes may be achieved by AC in periviable infants. Moreover, impaired neurodevelopmental outcomes may be associated with early postnatal acidemia following initial resuscitation.

摘要