Developmental Biology and Cancer Research and Teaching Department, UCL GOS Institute of Child Health, London, UK.
Department of Histopathology, Great Ormond Street Hospital, London, UK.
Childs Nerv Syst. 2024 Oct;40(10):3189-3207. doi: 10.1007/s00381-024-06591-6. Epub 2024 Sep 18.
Low-grade gliomas are a cause of severe and often life-long disability in children. Pathology plays a key role in their management by establishing the diagnosis, excluding malignant alternatives, predicting outcomes and identifying targetable genetic alterations. Molecular diagnosis has reshaped the terrain of pathology, raising the question of what part traditional histology plays. In this review, we consider the classification and pathological diagnosis of low-grade gliomas and glioneuronal tumours in children by traditional histopathology enhanced by the opportunities afforded by access to comprehensive genetic and epigenetic characterisation.
低级别胶质瘤是导致儿童严重且常常是终身残疾的一个原因。通过明确诊断、排除恶性肿瘤的其他可能、预测结果和确定可靶向的遗传改变，病理在其治疗中发挥着关键作用。分子诊断改变了病理学的面貌，提出了传统组织病理学发挥作用的问题。在这篇综述中，我们通过综合的遗传和表观遗传学特征分析来考虑传统组织病理学增强的机会，考虑儿童低级别胶质瘤和神经胶质神经元肿瘤的分类和病理诊断。
