Egas Moniz School of Health & Science, Egas Moniz Center for Interdisciplinary Research (CiiEM), Caparica, 2829-511, Portugal.
BMC Oral Health. 2024 Sep 18;24(1):1106. doi: 10.1186/s12903-024-04793-7.
Photobiomodulation (PBM) is a laser-based therapy used to promote tissue repair, reduce inflammation and pain, and has been extensively studied in chemo- and radiotherapy-induced oral mucositis (OM). This review examines the level of evidence of systematic reviews (SRs) that have investigated PBM in such cases of OM.
SRs evaluating PBM for both the treatment and prevention of OM in patients undergoing chemotherapy and/or radiotherapy and published before November 30, 2023, on PubMed, Cochrane, Embase, Web of Science, LILACS, TRIP and Open Grey databases were eligible for inclusion. We assessed the level of methodological and meta-analytic procedures.
Of the 1201 SRs, 21 that met the inclusion criteria were included. The quality of evidence was assessed using the Assessing the Measurement Tool to Assess Systematic Reviews (AMSTAR2), and the majority was of critically low quality (n = 15, 71.4%) with only 28.5% of low quality. A total of 40 meta-analytic estimates were obtained and analyzed. Approximately 87.5% of the meta-analysis were significant (n = 33), but only one meta-analyses had a strength of "highly suggestive", while the rest were classified as "weak". When analyzing the overlap values, the covered area was 12.14% and the corrected covered area was 7.75%, indicating a moderate overlap. Only 4 SRs had a very high overlap and one had a high overlap.
The efficacy of PBM in the treatment of chemotherapy-induced OM is supported by low to critically low quality SRs and meta-analysis of low strength. This review highlights important areas that need to be addressed in future research on this topic.
CRD42023484013 (PROSPERO).
光生物调节（PBM）是一种基于激光的治疗方法，用于促进组织修复、减轻炎症和疼痛，并已在化疗和放疗引起的口腔黏膜炎（OM）中得到广泛研究。本综述检查了调查 PBM 在这种 OM 情况下的疗效的系统评价（SR）的证据水平。
符合纳入标准的是评估 PBM 治疗和预防接受化疗和/或放疗的患者 OM 的 SR，并且在 2023 年 11 月 30 日之前在 PubMed、Cochrane、Embase、Web of Science、LILACS、TRIP 和 Open Grey 数据库上发表。我们评估了方法学和荟萃分析程序的水平。
在 1201 篇 SR 中，有 21 篇符合纳入标准。使用评估系统评价测量工具（AMSTAR2）评估证据质量，大多数为严重低质量（n=15，71.4%），仅有 28.5%为低质量。共获得并分析了 40 项荟萃分析估计值。大约 87.5%的荟萃分析具有统计学意义（n=33），但仅有一项荟萃分析具有“高度提示性”的强度，而其余则归类为“弱”。当分析重叠值时，覆盖面积为 12.14%，校正后的覆盖面积为 7.75%，表明重叠程度适中。只有 4 项 SR 的重叠度非常高，1 项的重叠度高。
低至严重低质量的 SR 和低强度荟萃分析支持 PBM 在治疗化疗引起的 OM 中的疗效。本综述强调了未来关于该主题的研究中需要解决的重要领域。
CRD42023484013（PROSPERO）。
