Department of Pediatrics, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Department of clinical and chemical pathology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Ital J Pediatr. 2024 Sep 18;50(1):182. doi: 10.1186/s13052-024-01735-5.
Pentraxin 3 (PTX3) is an acute-phase reactant that is elevated in the plasma during inflammatory responses. We aimed to evaluate the utility of PTX3 as a clinical marker in children with lower respiratory tract infections (LRTIs) and the association between PTX3 and LRTIs severity.
We included 60 patients admitted to Fayoum University Hospital with LRTIs fulfilling the WHO criteria for diagnosing LRTIs. We collected data on peak temperature, respiratory rate, heart rate, oxygen saturation upon admission, and length of hospital stay. The complete blood count (CBC), C-reactive protein (CRP) level, and PTX3 were measured upon admission.
PTX3 levels were significantly correlated with peak temperature, duration of hospital stay, the Pediatric Respiratory Severity Score (PRESS), total leucocytic count (TLC), CRP, and blood cultures.
PTX-3 represented the severity of the disease and predicted the prognosis. Pentraxin levels demonstrate a statistically significant sensitivity of (93.3%) and a specificity of (70%) at the cut-off value (of 8.84) with an area under the curve (90.7%) in the diagnosis of LRTIs.
血清正五聚蛋白 3（PTX3）是一种急性时相反应物，在炎症反应期间血浆中升高。我们旨在评估 PTX3 作为下呼吸道感染（LRTIs）患儿的临床标志物的效用，以及 PTX3 与 LRTIs 严重程度之间的关系。
我们纳入了 60 名因符合世界卫生组织（WHO）诊断 LRTIs 标准而入住法尤姆大学医院的 LRTIs 患者。我们收集了入院时的最高体温、呼吸频率、心率、血氧饱和度和住院时间的数据。入院时测量全血细胞计数（CBC）、C 反应蛋白（CRP）水平和 PTX3。
PTX3 水平与最高体温、住院时间、儿科呼吸严重程度评分（PRESS）、总白细胞计数（TLC）、CRP 和血培养呈显著相关。
PTX-3 代表疾病的严重程度并预测预后。Pentraxin 水平在诊断 LRTIs 时，在截断值（8.84）处表现出统计学上显著的敏感性（93.3%）和特异性（70%），曲线下面积（90.7%）。
