Schmitt K, Tulzer W
Wien Med Wochenschr. 1985 Jun 30;135(12):294-7.
The recommendations of the growth hormone dose for the treatment of growth hormone deficiency are similar, but there is still some uncertainty about the question which dose is optimal for the patients needs. The results of 10 patients with growth hormone deficiency are discussed. The indication to change the weekly dose from 8 IU to 12 IU growth hormone was dependent on the growth velocity. The mean growth velocities were: 7.61 cm for the first year, 6.22 cm for the second year, 6.21 cm for the third year and 6.66 cm for the fourth year. At any time, when we increased the dose, we saw an increment of the height afterwards. It remains to be determined, whether it means, that the genetically existing growth potential can be stimulated any time. When we compare the mean height velocity for the first 4 years with the results of other groups, we can see, that we did not lose growth power despite the late change to a third growth hormone injection. The mean growth velocity of the first 4 treatment years was 6.67 cm.
生长激素缺乏症治疗中生长激素剂量的推荐方案相似，但对于哪种剂量最符合患者需求仍存在一些不确定性。本文讨论了10例生长激素缺乏症患者的治疗结果。将生长激素每周剂量从8国际单位改为12国际单位的依据是生长速度。平均生长速度分别为：第一年7.61厘米，第二年6.22厘米，第三年6.21厘米，第四年6.66厘米。在任何时候，当我们增加剂量后，患者身高都会有所增长。目前尚有待确定，这是否意味着可以随时激发基因中存在的生长潜力。当我们将前4年的平均身高增长速度与其他组的结果进行比较时，可以发现，尽管较晚才改为每日三次注射生长激素，但我们并未丧失生长能力。前4年治疗的平均生长速度为6.67厘米。
