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空气质量与精神疾病:生物气溶胶的作用、因果机制及研究重点

Air quality and mental illness: role of bioaerosols, causal mechanisms and research priorities.

作者信息

Bhui Kamaldeep, Ucci Marcella, Kumar Prashant, Jackson Simon K, Whitby Corinne, Colbeck Ian, Pfrang Christian, Nasir Zaheer A, Coulon Frederic

机构信息

Department of Psychiatry and Nuffield Department of Primary Care Health Science, Wadham College, University of Oxford, Oxford, UK; and Global Policy Institute, Queen Mary University of London, London, UK.

UCL Institute for Environmental Design and Engineering, London, UK.

出版信息

BJPsych Open. 2024 Sep 19;10(5):e149. doi: 10.1192/bjo.2024.724.

Abstract

BACKGROUND

Poor air quality can both trigger and aggravate lung and heart conditions, as well as affecting child development. It can even lead to neurological and mental health problems. However, the precise mechanisms by which air pollution affect human health are not well understood.

AIMS

To promote interdisciplinary dialogue and better research based on a critical summary of evidence on air quality and health, with an emphasis on mental health, and to do so with a special focus on bioaerosols as a common but neglected air constituent.

METHOD

A rapid narrative review and interdisciplinary expert consultation, as is recommended for a complex and rapidly changing field of research.

RESULTS

The research methods used to assess exposures and outcomes vary across different fields of study, resulting in a disconnect in bioaerosol and health research. We make recommendations to enhance the evidence base by standardising measures of exposure to both particulate matter in general and bioaerosols specifically. We present methods for assessing mental health and ideal designs. There is less research on bioaerosols, and we provide specific ways of measuring exposure to these. We suggest research designs for investigating causal mechanisms as important intermediate steps before undertaking larger-scale and definitive studies.

CONCLUSIONS

We propose methods for exposure and outcome measurement, as well as optimal research designs to inform the development of standards for undertaking and reporting research and for future policy.

摘要

背景

空气质量差会引发并加重肺部和心脏疾病,还会影响儿童发育。甚至会导致神经和心理健康问题。然而,空气污染影响人类健康的确切机制尚未得到充分理解。

目的

基于对空气质量与健康证据的批判性总结,促进跨学科对话并开展更好的研究,重点关注心理健康,并特别关注生物气溶胶这一常见但被忽视的空气成分。

方法

采用快速叙述性综述和跨学科专家咨询,这是针对复杂且快速变化的研究领域所推荐的方法。

结果

用于评估暴露和结果的研究方法在不同研究领域存在差异,导致生物气溶胶与健康研究出现脱节。我们建议通过标准化一般颗粒物尤其是生物气溶胶的暴露测量方法来加强证据基础。我们介绍了评估心理健康的方法和理想的研究设计。关于生物气溶胶的研究较少,我们提供了测量接触生物气溶胶的具体方法。我们建议在开展大规模确定性研究之前,将研究因果机制的研究设计作为重要的中间步骤。

结论

我们提出了暴露和结果测量方法以及最佳研究设计,以为开展和报告研究的标准制定以及未来政策提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2451/11457254/267d14ef4f81/S2056472424007245_fig1.jpg

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