Demir Meryem, Kouranos Vasileios, Stoenchev Kostadin, Durham Stephen R, Scadding Guy W, Morar Nilesh, Al Yaghchi Chadwan, Sandhu Guri S, Saleh Hesham
Royal Brompton Hospital London, Guy's, and St Thomas' NHS Foundation Trust, London, UK.
Internal Medicine, Allergy and Clinical Immunology, Ege University Faculty of Medicine, Izmir, Turkey.
Laryngoscope. 2025 Feb;135(2):829-832. doi: 10.1002/lary.31778. Epub 2024 Sep 19.
Sarcoidosis is an inflammatory, non-caseating granulomatous multisystem disease associated with JAK-STAT (Janus kinases-signal transducer and activator of transcription proteins) pathway activation. We present a patient with severe multi-systemic sarcoidosis who showed marked improvement with tofacitinib with regards to pulmonary, cutaneous, nasal and laryngeal disease. Tofacitinib prevented critical laryngeal stenosis from progressing to tracheostomy, induced regression of cutaneous lesions and improved pulmonary function in this steroid-resistant and immunosuppressive intolerant case. This case report supports further the role of JAK-inhibitors in the treatment of systemic sarcoidosis. Laryngoscope, 135:829-832, 2025.
结节病是一种与JAK-STAT（Janus激酶-信号转导和转录激活蛋白）通路激活相关的炎症性、非干酪样肉芽肿性多系统疾病。我们报告了一名患有严重多系统结节病的患者，其肺部、皮肤、鼻腔和喉部疾病在使用托法替布后有显著改善。在这个对类固醇耐药且不耐受免疫抑制的病例中，托法替布防止了严重的喉狭窄进展为气管造口术，促使皮肤病变消退并改善了肺功能。本病例报告进一步支持了JAK抑制剂在系统性结节病治疗中的作用。《喉镜》，135:829 - 832，2025年。
