Chen Xueping, Chen Sihui, Lai Xiaohui, Fu Jiajia, Yang Jing, Ou Ruwei, Zhang Lingyu, Wei Qianqian, Guo Xiaoyan, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Front Cell Neurosci. 2024 Sep 4;18:1459884. doi: 10.3389/fncel.2024.1459884. eCollection 2024.
The association between cytokines in peripheral blood and clinical symptoms of multiple system atrophy (MSA) has been explored in only a few studies with small sample size, and the results were obviously controversial. Otherwise, no studies have explored the diagnostic value of serum cytokines in MSA.
Serum cytokines, including interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor alpha (TNF-α), were measured in 125 MSA patients and 98 healthy controls (HCs). Correlations of these serum cytokines with clinical variables were analyzed in MSA patients. Diagnostic value of cytokines for MSA was plotted by receiver operating curves.
No significant differences were found in sex and age between the MSA group and the HCs. TNF-α in MSA patients were significantly higher than those in HCs (area under the curve (AUC) 0.768), while IL-6 and IL-8 were not. Only Hamilton Anxiety Scale (HAMA) has a positive correlation between with TNF-α in MSA patients with age and age at onset as covariates. Serum IL-6 was associated with HAMA, Hamilton Depression Scale (HAMD), the Unified MSA Rating Scale I (UMSARS I) scores, the UMSARS IV and the Instrumental Activity of Daily Living scores. However, IL-8 was not associated with all clinical variables in MSA patients. Regression analysis showed that HAMA and age at onset were significantly associated with TNF-α, and only HAMA was mild related with IL-6 levels in MSA patients.
Serum TNF-α and IL-6 levels in MSA patients may be associated with anxiety symptom; however, only TNF-α was shown to be a useful tool in distinguishing between MSA and HCs.
仅有少数小样本研究探讨了外周血细胞因子与多系统萎缩（MSA）临床症状之间的关联，结果存在明显争议。此外，尚无研究探讨血清细胞因子在MSA中的诊断价值。
检测了125例MSA患者和98例健康对照者（HCs）的血清细胞因子，包括白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子α（TNF-α）。分析了这些血清细胞因子与MSA患者临床变量之间的相关性。通过绘制受试者工作曲线来评估细胞因子对MSA的诊断价值。
MSA组和HCs在性别和年龄方面无显著差异。MSA患者的TNF-α显著高于HCs（曲线下面积（AUC）为0.768），而IL-6和IL-8则无此差异。仅在以年龄和发病年龄作为协变量的MSA患者中，汉密尔顿焦虑量表（HAMA）与TNF-α呈正相关。血清IL-6与HAMA、汉密尔顿抑郁量表（HAMD）、统一MSA评定量表I（UMSARS I）评分、UMSARS IV和日常生活工具性活动评分相关。然而，IL-8与MSA患者的所有临床变量均无关联。回归分析显示，HAMA和发病年龄与TNF-α显著相关，在MSA患者中仅HAMA与IL-6水平轻度相关。
MSA患者血清TNF-α和IL-6水平可能与焦虑症状有关；然而，仅TNF-α被证明是区分MSA和HCs的有用工具。
