Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, P. R. China.
J Alzheimers Dis. 2022;87(4):1713-1723. doi: 10.3233/JAD-215688.
Dietary inflammatory index (DII) was associated with Type 2 diabetes mellitus and cognitive function impairment (CFI).
The aim of this study was to explore whether the associations among DII, glycohemoglobin (HbA1c), and CFI were similar in the participants with or without diabetes.
A total of 1,198 participants aged 60 and over from the National Health and Nutrition Examination Survey (NHANES) in 2011-2014 were involved in this study, dividing into subgroups as diabetes and non-diabetes for further analysis.
We found that participants with pro-inflammatory diet had higher proportion of CFI patients (p < 0.05). Pro-inflammatory diet and HbA1c were positively associated with the risk of CFI; participants with pro-inflammatory diet was 1.479 times on occurrence of CFI compared with anti-inflammatory diet group. The interaction between inflammatory diet and HbA1c was positive on the risk of CFI and was negative on the CERAD-immediate and CERAD-delayed, respectively. Among the participants without diabetes, the associations of Energy-adjusted DII (E-DII) with Animal Fluency test and Digit Symbol Substitution Test (DSST) were partially mediated by HbA1c, and the mediated proportion was 5.8% and 6.6%, respectively. However, there was no such mediation effect in the diabetes patients.
In elderly participants without diabetes, there was an interaction between inflammatory diet and HbA1c on the association with CFI, especially for the dimension of CERAD-immediate and CERAD-delayed. Besides, the associations of E-DII with Animal Fluency test and DSST were partially mediated by HbA1c. For diabetic patients, HbA1c, rather than the inflammatory diet has a positive effect on the CFI risk.
饮食炎症指数（DII）与 2 型糖尿病和认知功能障碍（CFI）有关。
本研究旨在探讨 DII、糖化血红蛋白（HbA1c）与 CFI 之间的关联在有或无糖尿病的参与者中是否相似。
本研究共纳入 2011-2014 年国家健康与营养调查（NHANES）中 1198 名年龄在 60 岁及以上的参与者，根据是否患有糖尿病分为亚组进行进一步分析。
我们发现，摄入促炎饮食的参与者中 CFI 患者的比例更高（p<0.05）。促炎饮食和 HbA1c 与 CFI 风险呈正相关；与抗炎饮食组相比，促炎饮食组发生 CFI 的风险增加了 1.479 倍。炎症饮食与 HbA1c 之间的相互作用对 CFI 的风险呈正相关，对 CERAD 即时和 CERAD 延迟呈负相关。在无糖尿病的参与者中，能量调整的 DII（E-DII）与动物流畅性测验和数字符号替代测验（DSST）的关联部分通过 HbA1c 介导，介导比例分别为 5.8%和 6.6%。然而，在糖尿病患者中没有这种中介效应。
在无糖尿病的老年参与者中，炎症饮食和 HbA1c 之间存在交互作用，影响 CFI 的发生，尤其是 CERAD 即时和 CERAD 延迟维度。此外，E-DII 与动物流畅性测验和 DSST 的关联部分通过 HbA1c 介导。对于糖尿病患者，HbA1c 而不是炎症饮食对 CFI 风险有积极影响。
