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非靶向代谢组学揭示了藜麦中独特苦味物质的特征。

Non-targeted metabolomics reveals the characteristics of the unique bitterness substances in quinoa.

作者信息

Huo Junqi, Feng Tingting, Shang Heting, Guo Chen, Wu Tianyu, Chu Mingjuan, Zhao Huixin, Wu Erbin, Li Hui, Wang Shuo, Wei Dong

机构信息

Hebei North University Hebei Key Laboratory of Analysis and Testing for Quality and Safety of Agricultural Products and Food, Hebei North University, Zhangjiakou, 075000, China.

Hebei North University College of Agriculture, Forestry and Technology, Zhangjiakou, 075000, China.

出版信息

Heliyon. 2024 Sep 2;10(17):e37133. doi: 10.1016/j.heliyon.2024.e37133. eCollection 2024 Sep 15.

DOI:10.1016/j.heliyon.2024.e37133
PMID:39296137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11409112/
Abstract

Bitterness is a key factor that affects the consumption of quinoa products, even if they are nutritious. In this study, a non-targeted metabolomics approach based on UHPLC-Orbitrap-MS was applied to comprehensively profile the characteristic metabolites of twenty-two quinoas. A total of twenty key metabolites were identified correlated with bitterness, among which, fifteen were triterpenoid saponins. In addition, these metabolites bind to the active site of the human bitter taste receptor and are the main compounds that produce the bitter taste of quinoa. Our results contribute to a deeper understanding of the origin of quinoa bitterness and provide directions for optimizing its flavor to improve market acceptance.

摘要

苦味是影响藜麦产品消费的关键因素，即便它们营养丰富。在本研究中，基于超高效液相色谱-静电场轨道阱质谱联用仪的非靶向代谢组学方法被用于全面剖析22种藜麦的特征代谢物。共鉴定出20种与苦味相关的关键代谢物，其中15种是三萜皂苷。此外，这些代谢物与人苦味受体的活性位点结合，是产生藜麦苦味的主要化合物。我们的研究结果有助于更深入地了解藜麦苦味的来源，并为优化其风味以提高市场接受度提供指导。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/ecdbe85bbd84/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/757c6d068390/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/31b10af9dc93/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/23724817ebdc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/92d59fcf6c5a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/36b679a66035/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/3e5f253c6959/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/31c682854b45/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/c5ee796da6d4/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/ecdbe85bbd84/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/757c6d068390/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/31b10af9dc93/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/23724817ebdc/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/92d59fcf6c5a/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/36b679a66035/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/3e5f253c6959/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/31c682854b45/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/c5ee796da6d4/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/41e6/11409112/ecdbe85bbd84/gr9.jpg

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Metabolomics Analysis of Different Quinoa Cultivars Based on UPLC-ZenoTOF-MS/MS and Investigation into Their Antioxidant Characteristics.基于超高效液相色谱-全二维质谱联用技术对不同藜麦品种的代谢组学分析及其抗氧化特性研究
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Predicting pathways for old and new metabolites through clustering.
通过聚类预测新旧代谢物的途径。
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Saponins from Chenopodium quinoa Willd. husks alleviated high-fat-diet-induced hyperlipidemia via modulating the gut microbiota and multiple metabolic pathways.藜麦（Chenopodium quinoa Willd.）麸皮中的皂苷通过调节肠道微生物群和多种代谢途径减轻高脂饮食诱导的高脂血症。
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