肿瘤坏死因子-α拮抗剂诱导的头皮银屑病中的瘢痕性脱发
Scarring Alopecia in Tumor Necrosis Factor-α Antagonists-Induced Scalp Psoriasis.
作者信息
Baniel Avital, Peled Alon, Samuelov Liat, Zemser Valentina, Gat Andrea, Dodiuk-Gad Roni P, Ziv Michael, Azzam Wassim, Zittan Eran, Matz Hagit, Sprecher Eli, Pavlovsky Mor
机构信息
Division of Dermatology, Tel Aviv Sourasky Medical Center, Israel.
Sackler Faculty of Medicine, TelAviv University, Israel.
出版信息
J Psoriasis Psoriatic Arthritis. 2023 Jul;8(3):90-95. doi: 10.1177/24755303231173376. Epub 2023 Apr 26.
BACKGROUND
A broad spectrum of adverse reactions associated with the use of tumor necrosis factor alpha (TNFα) antagonists has been recognized over the past years. Induction of scalp psoriasis is a less known undesirable consequence of the use of these drugs and is not well characterized.
OBJECTIVE
To characterize TNFα inhibitors-induced psoriatic alopecia.
METHODS
We studied 6 patients with TNF-inhibitor induced psoriatic alopecia and reviewed 28 patients with this condition reported in the literature to date.
RESULTS
In addition to severe scalp psoriasis, we report hair follicle pathologies ranging from alopecia areata to scarring alopecia. Prognosis was good, but discontinuation of TNFα inhibitors was required in more than half of the cases in order to achieve a favourable outcome.
CONCLUSION
TNFα inhibitors-associated psoriatic alopecia is rarely reported but requires a high index of suspicion and prompt diagnosis, as timely intervention may prevent irreversible damage.
背景
在过去几年中，人们已经认识到与使用肿瘤坏死因子α（TNFα）拮抗剂相关的一系列不良反应。头皮银屑病的诱发是使用这些药物较少为人所知的不良后果，且特征尚不明确。
目的
明确TNFα抑制剂诱发的银屑病性脱发的特征。
方法
我们研究了6例TNF抑制剂诱发的银屑病性脱发患者，并回顾了迄今为止文献报道的28例此类患者。
结果
除严重的头皮银屑病外，我们还报告了从斑秃到瘢痕性脱发的毛囊病变。预后良好，但超过半数的病例需要停用TNFα抑制剂才能取得良好疗效。
结论
TNFα抑制剂相关的银屑病性脱发虽鲜有报道，但需要高度怀疑并及时诊断，因为及时干预可能预防不可逆损害。
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