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银屑病性脱发

Psoriatic alopecia.

作者信息

George S M C, Taylor M R, Farrant P B J

机构信息

Department of Dermatology, Eastbourne District General Hospital, Eastbourne, UK.

Department of Pathology, Brighton and Sussex University Hospitals NHS Trust, Brighton, UK.

出版信息

Clin Exp Dermatol. 2015 Oct;40(7):717-21. doi: 10.1111/ced.12715. Epub 2015 Jul 23.

Abstract

Alopecia and other hair abnormalities occurring in patients with psoriasis were first recognized over four decades ago, yet psoriatic alopecia is not a well-known concept among clinicians. Alopecia may be directly related to the psoriasis itself, and can affect both the scalp and other parts of the body. On the scalp, psoriatic alopecia most commonly affects lesional skin, but may present as a generalized telogen effluvium. In most cases, there is regrowth of hair, but in rare cases it can cause scarring alopecia. Histological findings include features of psoriasis in the interfollicular epithelium, along with perifollicular inflammation and atrophy or loss of the sebaceous glands. Late changes include destruction of the hair follicle, with perifollicular fibrosis and 'naked' hair shafts lying free in the dermis. In addition to the hair loss caused by the psoriasis itself, data from population and genetic studies reveal that patients with psoriasis are at greater risk of developing alopecia areata. Psoriasis treatments may also contribute to hair loss. Application of topical preparations may cause hair loss through friction, and many of the systemic treatments used for psoriasis can also cause hair problems. Treatment with anti-tumour necrosis factor-α agents can precipitate de novo psoriasis and subsequent psoriatic alopecia.

摘要

银屑病患者出现的脱发及其他毛发异常早在四十多年前就已被首次认识到,但银屑病性脱发在临床医生中并非一个广为人知的概念。脱发可能与银屑病本身直接相关,可累及头皮和身体其他部位。在头皮上,银屑病性脱发最常累及皮损部位的皮肤,但也可能表现为广泛性休止期脱发。在大多数情况下,毛发会再生,但在极少数情况下,可导致瘢痕性脱发。组织学表现包括毛囊间上皮的银屑病特征,伴有毛囊周围炎症以及皮脂腺萎缩或缺失。后期改变包括毛囊破坏,伴有毛囊周围纤维化以及真皮内游离的“裸”毛干。除了银屑病本身导致的脱发外,人群和遗传学研究数据显示,银屑病患者发生斑秃的风险更高。银屑病的治疗也可能导致脱发。外用制剂的应用可能因摩擦导致脱发,许多用于治疗银屑病的全身治疗方法也可能引发毛发问题。使用抗肿瘤坏死因子-α制剂进行治疗可诱发新发银屑病及随后的银屑病性脱发。

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