血清胎球蛋白-A能否用作银屑病患者心血管受累的标志物？
Can Serum Fetuin-A be Used as a Marker for Cardiovascular Involvement in Psoriatic Patients?
作者信息
Saleh Hanan M, Sheha Aliaa S, Eskander Nardeen N, Elhawatky Ahmed F, Hassen Samah I
机构信息
Dermatology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Radio Diagnosis Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
J Psoriasis Psoriatic Arthritis. 2023 Apr;8(2):66-73. doi: 10.1177/24755303221135570. Epub 2023 Feb 15.
BACKGROUND
Psoriasis is a systemic inflammatory disorder. It is associated with increased risk of developing other chronic health diseases such cardiovascular disorders. Fetuin A is a glycoprotein that is present in blood serum. It may prevent vascular calcification by forming calciprotien particles; which are formed from their attachment with phosphate and calcium complexes.
AIM
The aim of this study was to measure serum Fetuin A in Psoriatic patients and correlate its level with cardiac events and risks in these patients using CT calcium (Ca) scoring.
PATIENTS AND METHODS
24 psoriatic patients (healthy without apparent cardiac risks to detect subclinical events if present) and 24 age and sex matched controls were tested for serum Fetuin A and underwent coronary calcium scoring by multidetector computed tomography (CT) scan. Psoriasis area and severity index (PASI) score for each patient was measured and was correlated with serum Fetuin A and CT calcium (Ca) scoring. Serum Fetuin A was compared between cases and controls and was correlated with coronary calcium score.
RESULTS
There was highly statistically significant decrease in serum Fetuin A level in psoriatic group compared to control group (-value < .001). There was highly statistically significant negative correlation between calcium score and the level of serum Fetuin A (-value < .001). No statistically significant correlation was found between the serum level of Fetuin A and the psoriasis severity.
CONCLUSION
Serum Fetuin A is a simple, easy diagnostic tool to evaluate subclinical atherosclerosis in psoriatic patients.
背景
银屑病是一种全身性炎症性疾病。它与患其他慢性健康疾病（如心血管疾病）的风险增加有关。胎球蛋白A是一种存在于血清中的糖蛋白。它可能通过形成钙蛋白颗粒来预防血管钙化；钙蛋白颗粒是由其与磷酸盐和钙复合物结合形成的。
目的
本研究的目的是测量银屑病患者的血清胎球蛋白A，并使用CT钙评分将其水平与这些患者的心脏事件及风险相关联。
患者与方法
对24例银屑病患者（健康且无明显心脏风险，以检测是否存在亚临床事件）和24例年龄及性别匹配的对照者进行血清胎球蛋白A检测，并通过多排螺旋计算机断层扫描（CT）进行冠状动脉钙化评分。测量每位患者的银屑病面积和严重程度指数（PASI）评分，并将其与血清胎球蛋白A和CT钙评分相关联。比较病例组和对照组的血清胎球蛋白A，并将其与冠状动脉钙化评分相关联。
结果
与对照组相比，银屑病组血清胎球蛋白A水平有高度统计学意义的降低（P值<0.001）。钙评分与血清胎球蛋白A水平之间存在高度统计学意义的负相关（P值<0.001）。未发现血清胎球蛋白A水平与银屑病严重程度之间存在统计学意义的相关性。
结论
血清胎球蛋白A是评估银屑病患者亚临床动脉粥样硬化的一种简单、易操作的诊断工具。
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