Clegg E J, Tills D, Warlow A, Wilkinson J, Marin A
Ann Hum Biol. 1985 Jul-Aug;12(4):345-61. doi: 10.1080/03014468500007881.
Blood groups and protein and enzyme polymorphism distributions were studied in 285 residents on the Isle of Lewis, in the Outer Hebrides. As well as gene frequency calculations for individual loci, genetic distance estimations were made and a phylogenetic tree was constructed. The results indicated several major differences from North-west European populations, with high values of R2(CDe), Rz(CDE) and P1. Among protein and enzyme polymorphisms Hp1, EAPA and PGM1(1) had very high frequencies. Genetic distances show Lewis to be unlike both Western and Eastern North European populations, while the phylogenetic tree shows a common, but rather distant, ancestry with Icelanders. This genetic uniqueness of Lewis as a whole is accompanied by a considerable degree of heterogeneity within the island itself, especially in the ABO and Rh systems. Stornoway, with a greater proportion of residents descended from immigrant stock, shows a greater degree of similarity with neighbouring populations. The reasons for both the overall uniqueness and the heterogeneity within Lewis are discussed, but in the absence of a large time-depth and adequate vital records, the various roles of selection, drift and migration in producing them are difficult to establish.
对外赫布里底群岛刘易斯岛的285名居民的血型以及蛋白质和酶多态性分布进行了研究。除了计算各个基因座的基因频率外，还进行了遗传距离估计并构建了系统发育树。结果表明，与西北欧人群存在几个主要差异，R2（CDe）、Rz（CDE）和P1的值较高。在蛋白质和酶多态性中，Hp1、EAPA和PGM1（1）的频率非常高。遗传距离表明刘易斯岛居民与北欧西部和东部人群均不相同，而系统发育树显示与冰岛人有共同但相当遥远的祖先。刘易斯岛整体的这种遗传独特性伴随着岛内相当程度的异质性，尤其是在ABO和Rh系统中。斯托诺韦有更大比例的居民是移民后裔，与邻近人群的相似程度更高。文中讨论了刘易斯岛整体独特性和异质性的原因，但由于缺乏长时间深度和足够的人口动态记录，难以确定选择、漂变和迁移在形成这些特征中所起的各种作用。
