坦桑尼亚达累斯萨拉姆特梅克6至59个月大儿童贫血的严重程度和形态学特征：基于诊所的横断面分析
Severity and Morphological Characteristics of Anaemia Among 6 to 59 Months Old Children in Temeke, Dar es Salaam-Tanzania: Clinics Based Cross Sectional Analysis.
作者信息
Omary Salha Ally, Kalabamu Florence Salvatory, Fataki Maulidi Rashidi, Salum Shani Shamsi, Mohamed Ummulkheir Hamid, Kimaro Joseph Gasper, Leshabari Kelvin Melkizedeck
机构信息
Department of Pediatrics/Child Health, Hubert Kairuki Memorial University, Dar es Salaam Tanzania.
Department of Pediatrics/Child Health, Temeke Regional Referral Hospital, Dar es Salaam Tanzania.
出版信息
East Afr Health Res J. 2024;8(2):188-194. doi: 10.24248/eahrj.v8i2.780. Epub 2024 Jun 26.
BACKGROUND
Anaemia is a global public health indicator of both poor nutrition and poor health. Besides, it stands as a silent signal of mal-aligned health system across the entire human lifespan. Globally, the importance of anaemia is most pronounced among children. This study was conceived to assess severity and morphological characteristics of anaemia among children aged from 6 to 59 months old in Temeke, Dar es Salaam, Tanzania.
METHODS
We designed a cross sectional, clinics-based analytical study. Children aged 6 to 59 months with anaemia were the target population. Severity and morphological characteristics of anaemia were the main outcome variables. Data were collected using a pre-designed questionnaire. Data were summarised using median and inter-quartile range (continuous variables) or frequency and proportions (categorical variables). Chi-square tests were applied to assess association between categorical variables. Alpha level of 5% was used as a limit of type 1 error in findings. Written informed consent was sought from mother of each child prior to inclusion into the study.
RESULTS
We successfully recruited and analysed 250 children. Participants median age was 17.5 (IQR: 9 - 34) months (females, n=112, 44.8%). Point prevalence of anaemia (Hb<12 g/dL) was 66.8%. Among anemic children (n=167), about 19%, 63% and 18% had mild, moderate and severe anaemia respectively. A direct linear association between MCV and MCHC was observed among anemic children (n=167, Spearman's rank ´Y= 0.86, ). There was a significant association between prevalence and severity of anaemia among studied children (LR χ (corrected) = 229.5, df=3). Majority (n=121, 72%) of the studied children had normocytic normochromic anaemia.
CONCLUSION
Majority of under-fives in attendance at outpatient clinics in Temeke were anemic. Normochromic normocytic anaemia was the most prevalent variant of anaemia in this study population.
背景
贫血是营养不良和健康状况不佳的一项全球公共卫生指标。此外，它是整个人类生命周期中健康系统失调的一个无声信号。在全球范围内，贫血的重要性在儿童中最为明显。本研究旨在评估坦桑尼亚达累斯萨拉姆特梅克地区6至59个月大儿童贫血的严重程度和形态学特征。
方法
我们设计了一项基于诊所的横断面分析研究。6至59个月患有贫血的儿童为目标人群。贫血的严重程度和形态学特征是主要的结局变量。使用预先设计的问卷收集数据。数据采用中位数和四分位数间距（连续变量）或频率和比例（分类变量）进行汇总。应用卡方检验评估分类变量之间的关联。在研究结果中，将5%的α水平用作I型错误的界限。在将每个儿童纳入研究之前，征求了其母亲的书面知情同意书。
结果
我们成功招募并分析了250名儿童。参与者的中位年龄为17.5（四分位间距：9 - 34）个月（女性，n = 112，44.8%）。贫血（血红蛋白<12 g/dL）的点患病率为66.8%。在贫血儿童（n = 167）中，分别约有19%、63%和18%患有轻度、中度和重度贫血。在贫血儿童（n = 167）中观察到平均红细胞体积（MCV）和平均红细胞血红蛋白浓度（MCHC）之间存在直接线性关联（Spearman等级相关系数γ = 0.86）。在研究儿童中，贫血的患病率和严重程度之间存在显著关联（似然比χ²（校正）= 229.5，自由度 = 3）。大多数（n = 121，72%）研究儿童患有正细胞正色素性贫血。
结论
在特梅克地区门诊就诊的大多数五岁以下儿童患有贫血。正色素性正细胞性贫血是本研究人群中最常见的贫血类型。
Zotero 插件