Faculty of Medicine, University of Sousse, Sousse, Tunisia.
Internal Medicine, Sahloul Hospital, Sousse, Sousse, 4011, Tunisia.
F1000Res. 2024 Sep 25;13:978. doi: 10.12688/f1000research.146952.1. eCollection 2024.
Bacterial infections continue to pose a global health challenge, driven by antibiotic resistance and septicemia. This study aimed to assess the diagnostic utility of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in bacterial infections versus non-infectious causes of inflammation.
A prospective study included 164 adult patients who were divided into two groups: a group of patients with confirmed bacterial infections and a second group of patients with other diagnoses (inflammatory pathologies, neoplasms, venous thromboembolic diseases, etc.). NLR and PLR values were compared between the bacterial infection group and the non-infectious causes group and the diagnostic performances of NLR and PLR for detecting bacterial infections were evaluated in comparison with other infection markers.
NLR and PLR were significantly higher in bacterial infections (p < 10 ), and NLR was correlated positively with inflammation markers. NLR and PLR demonstrated significant potential in diagnosing bacterial infections, with an AUC of 0.72 and 0.60, respectively, using the following cutoff values: 4.3 for NLR and 183 for PLR.
These findings underscore the importance of NLR and PLR as adjunctive tools for bacterial infection diagnosis.
由于抗生素耐药性和败血症的存在，细菌感染仍然对全球健康构成挑战。本研究旨在评估中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）在细菌感染与非感染性炎症病因中的诊断效用。
一项前瞻性研究纳入了 164 例成年患者，将其分为两组：一组为确诊的细菌感染患者，另一组为其他诊断患者（炎症性病变、肿瘤、静脉血栓栓塞性疾病等）。比较细菌感染组与非感染性病因组的 NLR 和 PLR 值，并与其他感染标志物比较，评估 NLR 和 PLR 对细菌感染的诊断性能。
细菌感染组的 NLR 和 PLR 显著升高（p<0.001），且 NLR 与炎症标志物呈正相关。NLR 和 PLR 对诊断细菌感染具有显著的潜在价值，截断值分别为 NLR 4.3 和 PLR 183 时，AUC 分别为 0.72 和 0.60。
这些发现强调了 NLR 和 PLR 作为细菌感染诊断辅助工具的重要性。
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