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病例报告：左旋多巴激发试验对于识别帕金森病患者中多巴胺诱导的步态冻结很重要。

Case report: Levodopa challenge test is important in identifying dopamine-induced freezing of gait in patient with Parkinson's disease.

作者信息

Xu Shan-Shan, Zhu Shi-Guo, Yuan Cheng-Xiang, Zeng Guo-Ling, Li Xiao-Tian, Liu Rong-Pei, Huang Shi-Shi, Zhang Xiong, Wang Jian-Yong

机构信息

Department of Neurology, Institute of Geriatric Neurology, the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.

出版信息

Front Hum Neurosci. 2024 Sep 4;18:1464152. doi: 10.3389/fnhum.2024.1464152. eCollection 2024.

DOI:10.3389/fnhum.2024.1464152
PMID:39296915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11408169/
Abstract

INTRODUCTION

Freezing of gait (FOG) is a disabling and heterogeneous symptom in patients with Parkinson's disease (PD). Among them, dopamine-induced FOG is rare and difficult to identify. The treatment of dopamine-induced FOG is complex.

CASE PRESENTATION

We herein presented a case of PD patient who complicated with refractory FOG. It was identified as dopamine-induced FOG during levodopa challenge test. Her symptoms were alleviated after we reduced the total equivalent dosage of levodopa.

CONCLUSION

Our report emphasizes the importance of levodopa challenge test in identifying different types of FOG, which is very important for further adjusting treatment.

摘要

引言

冻结步态（FOG）是帕金森病（PD）患者中一种致残且异质性的症状。其中，多巴胺诱导的FOG罕见且难以识别。多巴胺诱导的FOG的治疗很复杂。

病例报告

我们在此报告一例合并难治性FOG的PD患者。在左旋多巴激发试验中被确定为多巴胺诱导的FOG。在我们降低左旋多巴的总等效剂量后，她的症状得到缓解。

结论

我们的报告强调了左旋多巴激发试验在识别不同类型FOG中的重要性，这对进一步调整治疗非常重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/11408169/d5a12a77b692/fnhum-18-1464152-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/11408169/d5a12a77b692/fnhum-18-1464152-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/57c1/11408169/d5a12a77b692/fnhum-18-1464152-g001.jpg

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本文引用的文献

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Carpets with visual cues can improve gait in Parkinson's disease patients: may be independent of executive function.带有视觉提示的地毯可以改善帕金森病患者的步态：可能与执行功能无关。
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