Zhu Lei, Yang Xin, Zhang Jiying, Wang Shuling, Wang Yulong, Wan Xing, Zhu Xiang, Song Xiuyu, Tong Zhongsheng, Yang Meng, Zhao Weipeng
Department of Molecular Imaging and Nuclear Medicine, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China.
Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy, National Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Front Cell Dev Biol. 2024 Sep 4;12:1421981. doi: 10.3389/fcell.2024.1421981. eCollection 2024.
Breast cancer is a heterogeneous disease comprising various molecular subtypes, including Luminal A, Luminal B, human epidermal growth factor receptor-2 (HER2) positive, and triple negative types, each with distinct biological characteristics and behaviors. Triple negative breast cancer (TNBC) remains a particularly challenging subtype worldwide. Our study aims to evaluate whether Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (F-FDG PET/CT) parameters, clinical pathological features, and biochemical indicators serve as prognostic risk factors for TNBC. Additionally, we explore correlations between biochemical indicators and F-FDG PET/CT parameters.
We conducted a retrospective analysis of 95 TNBC patients who underwent preoperative F-FDG PET/CT examinations at Tianjin Medical University Cancer Institute and Hospital from 2013 to 2018. Collected data included F-FDG PET/CT parameters, clinical and pathological features, and biochemical indicators. We used Kaplan-Meier survival analysis and multivariate Cox regression analysis to evaluate associations between F-FDG PET/CT parameters/biochemical indicators and disease free survival (DFS)/overall survival (OS). The log-rank test determined significant differences in survival curves, and the Spearman correlation coefficient analyzed correlations between quantitative variables. Visualization and analysis were performed using R packages.
Among 95 TNBC patients, mean standardized uptake value (SUV) was significantly correlated with DFS. Fasting blood glucose (FBG), α- L-fucosylase (AFU) and Creatine kinase (CK) were independent predictors of DFS, while Precursor albumin (PALB) and CK were independent predictors of OS. FBG showed correlations with SUV and SUV, and CK was correlated with peak standardized uptake value (SUV). Our results indicated that F-FDG PET/CT parameters and biochemical indicators may constitute a new prognostic model for TNBC patients post-surgery.
We found that SUV, FBG, AFU and CK are predictive factors for DFS in TNBC patients post-surgery, while PALB and CK are predictive factors for OS, which prompts us to pay more attention to these indicators in clinical practice. Also F-FDG PET/CT parameters and biochemical indicators have potential utility in constituting a new prognostic model for TNBC patients post-surgery.
乳腺癌是一种异质性疾病，包含多种分子亚型，包括腔面A型、腔面B型、人表皮生长因子受体2（HER2）阳性型和三阴性型，每种亚型都具有独特的生物学特征和行为。三阴性乳腺癌（TNBC）在全球范围内仍然是一种特别具有挑战性的亚型。我们的研究旨在评估氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）参数、临床病理特征和生化指标是否可作为TNBC的预后危险因素。此外，我们还探讨了生化指标与F-FDG PET/CT参数之间的相关性。
我们对2013年至2018年在天津医科大学肿瘤医院接受术前F-FDG PET/CT检查的95例TNBC患者进行回顾性分析。收集的数据包括F-FDG PET/CT参数、临床和病理特征以及生化指标。我们使用Kaplan-Meier生存分析和多变量Cox回归分析来评估F-FDG PET/CT参数/生化指标与无病生存期（DFS）/总生存期（OS）之间的关联。对数秩检验确定生存曲线的显著差异，Spearman相关系数分析定量变量之间的相关性。使用R软件包进行可视化和分析。
在95例TNBC患者中，平均标准化摄取值（SUV）与DFS显著相关。空腹血糖（FBG）、α-L-岩藻糖苷酶（AFU）和肌酸激酶（CK）是DFS的独立预测因素，而前白蛋白（PALB）和CK是OS的独立预测因素。FBG与SUV和最大标准化摄取值（SUVmax）相关，CK与峰值标准化摄取值（SUVpeak）相关。我们的结果表明，F-FDG PET/CT参数和生化指标可能构成TNBC患者术后的一种新的预后模型。
我们发现SUV、FBG、AFU和CK是TNBC患者术后DFS的预测因素，而PALB和CK是OS的预测因素，这促使我们在临床实践中更加关注这些指标。此外，F-FDG PET/CT参数和生化指标在构成TNBC患者术后的新预后模型方面具有潜在用途。
