Li Xiaojing, Wu Liuting, Bai Dunyao, Li Juan
Department of Pharmacy, Puren Hospital of Wuhan University of Science and Technology, Wuhan, Hubei, China.
Department of Pharmacy, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Front Oncol. 2024 Sep 4;14:1440205. doi: 10.3389/fonc.2024.1440205. eCollection 2024.
Despite its excellent therapeutic efficacy, albumin-bound paclitaxel often leads to peripheral neurotoxicity, significantly affecting patients' quality of life. This study reported a case of non-small cell lung cancer (NSCLC) with peripheral neurotoxicity induced by albumin-bound paclitaxel.
A 70-year-old male was admitted to the Hubei Cancer Hospital complaining of left-side limb weakness and numbness for one month following the first cycle of albumin paclitaxel plus cisplatin plus tislelizumab regimen for the right-side NSCLC in December 2021. Chest CT displayed a soft tissue density mass in the apical segment of the right upper lung lobe (5.5×4.9 cm). Immunohistochemistry results and CT-guided percutaneous lung biopsy confirmed NSCLC stage cTNM. The pain and numbness in both feet were alleviated after the first cycle of this regimen of liposomal paclitaxel 240 mg plus cisplatin 90 mg plus tislelizumab 200 mg. After four treatment cycles, the tumor treatment was evaluated as partial response (PR), and the tumor lesion became 2.9×2.7 cm.
The regimen containing liposomal paclitaxel, cisplatin, and tislelizumab alleviated the symptoms of peripheral neurotoxicity induced by albumin-bound paclitaxel in an NSCLC case, which may be a potential therapeutic option.
尽管白蛋白结合型紫杉醇具有出色的治疗效果，但它常导致周围神经毒性，严重影响患者的生活质量。本研究报告了一例因白蛋白结合型紫杉醇引起周围神经毒性的非小细胞肺癌（NSCLC）病例。
一名70岁男性因2021年12月接受白蛋白紫杉醇联合顺铂加替雷利珠单抗方案治疗右侧非小细胞肺癌的第一个周期后，出现左侧肢体无力和麻木一个月，入住湖北省肿瘤医院。胸部CT显示右上肺叶尖段有一软组织密度肿块（5.5×4.9厘米）。免疫组化结果及CT引导下经皮肺穿刺活检确诊为非小细胞肺癌cTNM分期。在使用脂质体紫杉醇240毫克联合顺铂90毫克加替雷利珠单抗200毫克的该方案第一个周期后，双足疼痛和麻木症状有所缓解。经过四个治疗周期后，肿瘤治疗评估为部分缓解（PR），肿瘤病灶变为2.9×2.7厘米。
含脂质体紫杉醇、顺铂和替雷利珠单抗的方案缓解了一例非小细胞肺癌病例中由白蛋白结合型紫杉醇引起的周围神经毒性症状，这可能是一种潜在的治疗选择。
