Assaf Roxane, Ouellet Julien, Bourque Josiane, Stip Emmanuel, Leyton Marco, Conrod Patricia, Potvin Stéphane
Centre de Recherche de l'Institut Universitaire en Santé Mentale De Montréal, Montreal, QC, Canada.
Department of Psychiatry and Addiction, Faculty of Medicine, University of Montreal, Montreal, QC, Canada.
Dev Psychopathol. 2025 Aug;37(3):1495-1504. doi: 10.1017/S0954579424001317. Epub 2024 Sep 19.
Social cognition is commonly altered in people with psychosis. Two main brain networks have been implicated: the default-mode network (DMN), which is associated with socio-cognitive processing, and the salience network (SN) associated with socio-affective processing. Disturbances to the resting-state functional connectivity of these networks have been identified in schizophrenia and high-risk individuals, but there have been no studies in adolescents displaying distinct trajectories of subclinical psychotic-like experiences (PLEs). To address this, the present study measured SN and DMN resting-state connectivity in a unique longitudinally followed sample of youth ( = 92) presenting with typical and atypical 4-year PLE trajectories. Compared to the typically developing low PLE control group, the atypical increasing PLE trajectory displayed reduced connectivity between the SN and DMN, increased connectivity between left and right insula, and widespread dysconnectivity from the insula and amygdala. These alterations are similar to those reported in schizophrenia and clinical high-risk samples, suggesting that early detection may be useful for mapping the developmental trajectories of psychotic disorders.
精神病患者的社会认知通常会发生改变。涉及两个主要的脑网络：与社会认知加工相关的默认模式网络（DMN），以及与社会情感加工相关的突显网络（SN）。在精神分裂症患者和高危个体中已发现这些网络静息态功能连接的紊乱，但尚未有针对表现出不同亚临床精神病性体验（PLEs）轨迹的青少年的研究。为解决这一问题，本研究在一个独特的纵向随访的青年样本（n = 92）中测量了SN和DMN的静息态连接，这些青年呈现出典型和非典型的4年PLE轨迹。与典型发育的低PLE对照组相比，非典型的PLE增加轨迹显示SN和DMN之间的连接减少，左右脑岛之间的连接增加，以及脑岛和杏仁核的广泛连接障碍。这些改变与精神分裂症和临床高危样本中报告的改变相似，表明早期检测可能有助于描绘精神障碍的发展轨迹。
