过量甲羟戊酸对梨形四膜虫中泛醌和四氢鲨烯醇生物合成的影响。
The effect of excess mevalonic acid on ubiquinone and tetrahymanol biosynthesis in Tetrahymena pyriformis.
作者信息
Wilton D C
出版信息
Biochem J. 1985 Jul 15;229(2):551-3. doi: 10.1042/bj2290551.
When T. pyriformis is grown in the presence of 10(-2)M-mevalonic acid, the uptake exceeds the cell's requirement for this biosynthetic intermediate. The majority of the excess mevalonic acid is diverted into ubiquinone-8 biosynthesis whereas the biosynthesis of tetrahymanol, the major product of the mevalonic acid pathway, is unchanged. In the presence of excess external mevalonic acid, the biosynthesis of mevalonic acid by the cell is inhibited. It is proposed that ubiquinone biosynthesis is normally regulated by mevalonic acid availability, whereas tetrahymanol biosynthesis is regulated primarily at a later point in the pathway.
当梨形四膜虫在10⁻²M-甲羟戊酸存在的情况下生长时，其摄取量超过了细胞对这种生物合成中间体的需求。大部分过量的甲羟戊酸被转而用于泛醌-8的生物合成，而甲羟戊酸途径的主要产物四膜虫醇的生物合成则保持不变。在存在过量外部甲羟戊酸的情况下，细胞中甲羟戊酸的生物合成受到抑制。有人提出，泛醌的生物合成通常受甲羟戊酸可用性的调节，而四膜虫醇的生物合成主要在该途径的后期受到调节。
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