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Differential diagnosis between Cushing's syndrome and non-neoplastic hypercortisolism: are we getting there?

作者信息

Pivonello Rosario, Simeoli Chiara, Di Paola Nicola, Colao Annamaria

机构信息

Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Diabetologia, Andrologia e Nutrizione, Università Federico II di Napoli, Naples, Italy.

Unesco Chair for Health Education and Sustainable Development, University Federico II, Naples, Italy.

出版信息

Pituitary. 2024 Oct;27(5):451-454. doi: 10.1007/s11102-024-01458-0. Epub 2024 Sep 19.

DOI:10.1007/s11102-024-01458-0
PMID:39298060
Abstract
摘要

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Differential diagnosis between Cushing's syndrome and non-neoplastic hypercortisolism: are we getting there?库欣综合征与非肿瘤性皮质醇增多症的鉴别诊断：我们做到了吗？
Pituitary. 2024 Oct;27(5):451-454. doi: 10.1007/s11102-024-01458-0. Epub 2024 Sep 19.
2
The conundrum of differentiating Cushing's syndrome from non-neoplastic hypercortisolism: a systematic review and meta-analysis.鉴别库欣综合征与非肿瘤性皮质醇增多症的难题：系统评价和荟萃分析。
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The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states.地塞米松抑制促肾上腺皮质激素释放激素刺激试验及去氨加压素试验用于鉴别库欣综合征与假性库欣状态。
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DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome).内分泌疾病的诊断：病理性/肿瘤性皮质醇增多症（库欣综合征）与生理性/非肿瘤性皮质醇增多症（以前称为假性库欣综合征）的鉴别。
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Corticotropin-releasing hormone stimulation following low-dose dexamethasone administration. A new test to distinguish Cushing's syndrome from pseudo-Cushing's states.小剂量地塞米松给药后促肾上腺皮质激素释放激素刺激试验。一种区分库欣综合征与假性库欣状态的新试验。
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The difficulties of pseudo-Cushing's syndrome (or "non-neoplastic hypercortisolism").假性库欣综合征（或“非肿瘤性皮质醇增多症”）的困难。
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Late-night salivary cortisol as a screening test for Cushing's syndrome.午夜唾液皮质醇作为库欣综合征的筛查试验。
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Pseudo-Cushing’s States假性库欣状态
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Pitfalls in the diagnosis and management of Cushing's syndrome.库欣综合征诊断与管理中的陷阱
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本文引用的文献

1
Accuracy of the 10 μg desmopressin test for differential diagnosis of Cushing syndrome: a systematic review and meta-analysis.10μg 去氨加压素试验鉴别诊断库欣综合征的准确性：系统评价和荟萃分析。
Front Endocrinol (Lausanne). 2024 Jan 30;15:1332120. doi: 10.3389/fendo.2024.1332120. eCollection 2024.
2
Recognition of Nonneoplastic Hypercortisolism in the Evaluation of Patients With Cushing Syndrome.库欣综合征患者评估中非肿瘤性皮质醇增多症的识别
J Endocr Soc. 2023 Jun 23;7(8):bvad087. doi: 10.1210/jendso/bvad087. eCollection 2023 Jul 3.
3
Second-line tests in the differential diagnosis of neoplastic and non-neoplastic hypercortisolism: a systematic review and meta-analysis.
二线检测在肿瘤性和非肿瘤性皮质醇增多症鉴别诊断中的应用：系统评价和荟萃分析。
J Endocrinol Invest. 2023 Oct;46(10):1947-1959. doi: 10.1007/s40618-023-02099-z. Epub 2023 Apr 20.
4
Consensus on diagnosis and management of Cushing's disease: a guideline update.库欣病的诊断和治疗共识：指南更新。
Lancet Diabetes Endocrinol. 2021 Dec;9(12):847-875. doi: 10.1016/S2213-8587(21)00235-7. Epub 2021 Oct 20.
5
DIAGNOSIS OF ENDOCRINE DISEASE: Differentiation of pathologic/neoplastic hypercortisolism (Cushing's syndrome) from physiologic/non-neoplastic hypercortisolism (formerly known as pseudo-Cushing's syndrome).内分泌疾病的诊断：病理性/肿瘤性皮质醇增多症（库欣综合征）与生理性/非肿瘤性皮质醇增多症（以前称为假性库欣综合征）的鉴别。
Eur J Endocrinol. 2017 May;176(5):R205-R216. doi: 10.1530/EJE-16-0946. Epub 2017 Feb 8.
6
Evaluation of the DDAVP test in the diagnosis of Cushing's Disease.去氨加压素试验在库欣病诊断中的评估
Clin Endocrinol (Oxf). 2015 Jun;82(6):793-800. doi: 10.1111/cen.12661. Epub 2014 Dec 22.
7
Comparisons in the epidemiology, diagnostic features and cure rate by transsphenoidal surgery between paediatric and adult-onset Cushing's disease.儿童和成人发病的库欣病经蝶窦手术的流行病学、诊断特征和治愈率比较。
Eur J Endocrinol. 2011 May;164(5):667-74. doi: 10.1530/EJE-10-1120. Epub 2011 Feb 10.
8
Use of the desmopressin test in the differential diagnosis of pseudo-Cushing state from Cushing's disease.使用去氨加压素试验鉴别库欣病与假性库欣状态。
J Clin Endocrinol Metab. 2010 Mar;95(3):1115-22. doi: 10.1210/jc.2009-1146. Epub 2010 Jan 15.
9
Concomitant medication use can confound interpretation of the combined dexamethasone-corticotropin releasing hormone test in Cushing's syndrome.在库欣综合征中，同时使用药物会混淆对联合地塞米松-促肾上腺皮质激素释放激素试验的解释。
J Clin Endocrinol Metab. 2009 Dec;94(12):4851-9. doi: 10.1210/jc.2009-1500. Epub 2009 Oct 22.
10
Severe obesity confounds the interpretation of low-dose dexamethasone test combined with the administration of ovine corticotrophin-releasing hormone in childhood Cushing syndrome.重度肥胖混淆了儿童库欣综合征中低剂量地塞米松试验联合注射羊促肾上腺皮质激素释放激素的结果解读。
J Clin Endocrinol Metab. 2008 Nov;93(11):4323-30. doi: 10.1210/jc.2008-0985. Epub 2008 Aug 26.