Ahn Gyo J, Lee Solam, Heo Yeon-Woo, Cha Yong S
Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.
Crit Care Med. 2024 Dec 1;52(12):1866-1876. doi: 10.1097/CCM.0000000000006414. Epub 2024 Sep 18.
Carbon monoxide (CO) poisoning can cause brain, heart, and kidney injuries. We aimed to determine the association of risks of all-cause and cause-specific mortality in patients with previous CO poisoning.
DESIGN, SETTING, AND PATIENTS: This population-based cohort study used data from the National Health Insurance Service database and the National Death Registry of Korea. Adult patients diagnosed with CO poisoning and controls between 2002 and 2020 were included. Patients were matched with controls on a 1:1 ratio, considering age, sex, insurance type, income level, residential location, smoking status, alcohol consumption, obesity status, medical and psychiatric illness history, and Charlson Comorbidity Index at the index date. The cohort was monitored from 2002 to 2022 or until death or emigration in terms of all-cause and cause-specific mortality.
None.
A total of 48,600 patients with CO poisoning and matched controls were included. The cohort included 41.30% females, and the mean age was 48.05 years. Patients with CO poisoning exhibited a substantially elevated risk of all-cause mortality compared with those in the control group, with an adjusted hazard ratio (aHR) of 15.67 (95% CI, 12.58-19.51). The mortality associated with infectious (aHR, 6.71; 95% CI, 1.51-29.72), neoplasm/oncologic (aHR, 5.20; 95% CI, 3.39-7.99), endocrine (aHR, 13.44; 95% CI, 1.76-102.70), neurologic (aHR, 7.42; 95% CI, 2.91-18.90), cardiovascular (aHR, 8.97; 95% CI, 5.05-15.93), respiratory (aHR, 17.54; 95% CI, 5.48-56.17), and gastrointestinal (aHR, 24.72; 95% CI, 3.34-182.69) disorders was significantly greater in the former. Deaths due to external causes, including suicide, were significantly higher in the CO poisoning group (aHR, 50.07; 95% CI, 30.98-80.90).
Patients with CO poisoning exhibited a heightened risk of all-cause mortality compared with the matched controls. Additionally, the cause-specific mortality risk differed between the groups.
一氧化碳（CO）中毒可导致脑、心和肾损伤。我们旨在确定既往有CO中毒患者的全因死亡风险和特定病因死亡风险之间的关联。
设计、设置和患者：这项基于人群的队列研究使用了韩国国民健康保险服务数据库和韩国国家死亡登记处的数据。纳入了2002年至2020年间被诊断为CO中毒的成年患者及对照组。根据年龄、性别、保险类型、收入水平、居住地点、吸烟状况、饮酒情况、肥胖状况、医疗和精神疾病史以及索引日期的Charlson合并症指数，将患者与对照组按1:1的比例进行匹配。从2002年至2022年对该队列进行全因死亡和特定病因死亡方面的监测，直至死亡或移民。
无。
共纳入48,600例CO中毒患者及匹配的对照组。该队列中女性占41.30%，平均年龄为48.05岁。与对照组相比，CO中毒患者的全因死亡风险显著升高，调整后的风险比（aHR）为15.67（95%CI，12.58 - 19.51）。前者因感染（aHR，6.71；95%CI，1.51 - 29.72）、肿瘤/肿瘤学（aHR，5.20；95%CI，3.39 - 7.99）、内分泌（aHR，13.44；95%CI，1.76 - 102.70）、神经（aHR，7.42；95%CI，2.91 - 18.90）、心血管（aHR，8.97；95%CI，5.05 - 15.93）、呼吸（aHR，17.54；95%CI，5.48 - 56.17）和胃肠道（aHR，24.72；95%CI，3.34 - 182.69）疾病导致的死亡风险显著更高。CO中毒组因包括自杀在内的外部原因导致的死亡显著更高（aHR，50.07；95%CI
