角膜塑形术联合 0.01%阿托品滴眼液对青少年近视的疗效。
Therapeutic effects of orthokeratology lens combined with 0.01% atropine eye drops on juvenile myopia.
机构信息
Department of Ophthalmology, Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated with Nanjing University of Chinese Medicine, Nanjing 210014, Jiangsu Province, China.
出版信息
Arq Bras Oftalmol. 2023 Apr 3;87(5):e20220247. doi: 10.5935/0004-2749.2022-0247. eCollection 2023.
PURPOSE
To explore the therapeutic effects of orthokeratology lens combined with 0.01% atropine eye drops on juvenile myopia.
METHODS
A total of 340 patients with juvenile myopia (340 eyes) treated from 2018 to December 2020 were divided into the control group (170 cases with 170 eyes, orthokeratology lens) and observation group (170 cases with 170 eyes, orthokeratology lens combined with 0.01% atropine eye drops). The best-corrected distance visual acuity, best-corrected near visual acuity, diopter, axial length, amplitude of accommodation, bright pupil diameter, dark pupil diameter, tear-film lipid layer thickness, and tear break-up time were measured before treatment and after 1 year of treatment. The incidence of adverse reactions was observed.
RESULTS
Compared with the values before treatment, the spherical equivalent degree was significantly improved by 0.22 (0.06, 0.55) D and 0.40 (0.15, 0.72) D in the observation and control groups after the treatment, respectively (p<0.01). After the treatment, the axial length was significantly increased by (0.15 ± 0.12) mm and (0.24 ± 0.11) mm in the observation and control groups, respectively, (p<0.01). After the treatment, the amplitude of accommodation significantly declined in the observation group and was lower than that in the control group, whereas both bright and dark pupil diameters significantly increase and were larger than those in the control group (p<0.01). After the treatment, the tear-film lipid layer thickness and tear break-up time significantly declined in the two groups (p<0.01).
CONCLUSIONS
Orthokeratology lens combined with 0.01% atropine eye drops can synergistically enhance the control effect on juvenile myopia with high safety.
目的
探讨角膜塑形镜联合 0.01%阿托品滴眼液治疗青少年近视的疗效。
方法
选取 2018 年 12 月至 2020 年期间收治的 340 例（340 眼）青少年近视患者，按照治疗方法的不同分为对照组（170 例 170 眼，角膜塑形镜）和观察组（170 例 170 眼，角膜塑形镜联合 0.01%阿托品滴眼液）。比较两组患者治疗前后最佳矫正远视力、最佳矫正近视力、屈光度、眼轴长度、调节幅度、明视瞳孔直径、暗视瞳孔直径、泪膜脂质层厚度、泪膜破裂时间，并观察不良反应发生情况。
结果
与治疗前比较，两组患者治疗后球镜度数分别改善 0.22（0.06，0.55）D、0.40（0.15，0.72）D（均 P<0.01），眼轴长度分别增加（0.15±0.12）mm、（0.24±0.11）mm（均 P<0.01）；观察组治疗后调节幅度明显下降，且低于对照组，明视瞳孔直径、暗视瞳孔直径均明显增大，且大于对照组（均 P<0.01）；两组患者治疗后泪膜脂质层厚度、泪膜破裂时间均明显下降（均 P<0.01）。
结论
角膜塑形镜联合 0.01%阿托品滴眼液治疗青少年近视可协同增效，安全性高。
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