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接种疫苗对感染 COVID-19 的可能性的影响。

The Impact of Vaccination on the Likelihood of COVID-19 Infection.

机构信息

Griffith University, Queensland, Australia.

Thai Nguyen University of Agriculture and Forestry, Thai Nguyen City, Vietnam.

出版信息

Viral Immunol. 2024 Sep;37(7):371-381. doi: 10.1089/vim.2024.0046.

Abstract

The current study investigates COVID-19 infection likelihood using data from 5,819 respondents in Vietnam and Indonesia (December 10, 2022, to March 27, 2023) through binary logistic regressions. Descriptive statistics highlight the significance of vaccination status, with almost half of unvaccinated respondents contracting the infection. The second vaccine dose showed the lowest infection percentages, suggesting a potential dose-dependent effect. Those receiving mRNA vaccines consistently had reduced infection likelihood across the first four doses, with an unexpected reversal for the fifth dose. Vaccinated individuals, especially with mRNA vaccines, had faster recovery times, and variability in recovery times and milder symptoms were observed in mRNA vaccine recipients. Regression results from Model 1 reveal a substantial impact of vaccination, with vaccinated respondents having ∼48.1% lower odds than the unvaccinated. Model 2 underscores a dose-dependent protective effect, with each additional dose associated with a notable 6.6% reduction in infection likelihood. Beyond vaccination, gender, family size, marital status, employment, urban residence, and nationality influenced infection likelihood. Males, larger families, single marital status, unemployment, rural residence, and Indonesian nationality increased the likelihood of infection. Surprisingly, respondents with infected family members exhibited a lower infection likelihood, suggesting potential protective measures within households. These findings highlight COVID-19 dynamics, and ongoing research refines comprehension.

摘要

本研究使用 2022 年 12 月 10 日至 2023 年 3 月 27 日期间来自越南和印度尼西亚的 5819 名受访者的数据,通过二项逻辑回归调查 COVID-19 感染的可能性。描述性统计数据强调了疫苗接种状况的重要性,近一半未接种疫苗的受访者感染了该病毒。第二剂疫苗显示出最低的感染百分比,表明可能存在剂量依赖性效应。接受 mRNA 疫苗的人在最初的四剂中感染的可能性持续降低,第五剂出现了意外的逆转。接种疫苗的人,特别是接受 mRNA 疫苗的人,恢复时间更快,并且在 mRNA 疫苗接种者中观察到恢复时间和症状的可变性。模型 1 的回归结果显示疫苗接种的显著影响,接种疫苗的受访者感染的几率比未接种疫苗的受访者低约 48.1%。模型 2 强调了剂量依赖性的保护效应,每增加一剂疫苗,感染的可能性就会显著降低 6.6%。除了疫苗接种外,性别、家庭规模、婚姻状况、就业状况、居住在城市和国籍也会影响感染的可能性。男性、家庭规模较大、单身、失业、居住在农村和印度尼西亚国籍会增加感染的可能性。令人惊讶的是,有感染家庭成员的受访者感染的可能性较低,这表明家庭内部可能采取了潜在的保护措施。这些发现突出了 COVID-19 的动态,并且正在进行的研究进一步加深了我们的理解。

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