Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Jiangxi Provincal Key Laboratory of Tissue Engineering, Scientific Research Center, Gannan Medical University, Ganzhou 341000, China.
Department of Anesthesiology, Ganzhou Key Laboratory of Anesthesiology, Ganzhou Key Laboratory of Osteoporosis Research, The First Affiliated Hospital of Gannan Medical University, Ganzhou 341000, China.
Biomed Pharmacother. 2024 Nov;180:117438. doi: 10.1016/j.biopha.2024.117438. Epub 2024 Sep 19.
Cancer poses a substantial global health challenge, necessitating the widespread use of chemotherapy and radiotherapy. Despite these efforts, issues like resistance development and severe side effects remain. As such, the search for more effective alternatives is critical. Andrographolide, a naturally occurring compound, has recently gained attention for its extensive biological activities. This review explores the role of andrographolide in cancer therapy, especially focusing on the molecular mechanisms that drive its anti-tumor properties. It also examines innovative methods to enhance andrographolide's bioavailability, thus boosting its effectiveness against cancer. Notably, andrographolide has potential for use in combination with various clinical drugs, and both preclinical and clinical studies provide strong evidence supporting its broader anticancer applications. Additionally, this paper proposes future research directions for andrographolide's anti-cancer effects and discusses the challenges in its clinical usage along with current research efforts to address these issues. In summary, this review underscores andrographolide's potential roles and contributes to the development of improved cancer treatment strategies.
癌症是一个全球性的重大健康挑战，需要广泛应用化疗和放疗。尽管有这些努力，像耐药性的发展和严重的副作用等问题仍然存在。因此，寻找更有效的替代方法至关重要。穿心莲内酯是一种天然存在的化合物，由于其广泛的生物活性而引起了人们的关注。本综述探讨了穿心莲内酯在癌症治疗中的作用，特别是重点研究了驱动其抗肿瘤特性的分子机制。还探讨了提高穿心莲内酯生物利用度的创新方法，从而提高其对癌症的疗效。值得注意的是，穿心莲内酯有可能与各种临床药物联合使用，临床前和临床研究都为其更广泛的抗癌应用提供了强有力的证据。此外，本文还提出了穿心莲内酯抗癌作用的未来研究方向，并讨论了其临床应用中的挑战以及目前为解决这些问题所做的研究努力。总之，本综述强调了穿心莲内酯的潜在作用，并为开发改进的癌症治疗策略做出了贡献。
