Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Key Laboratory of Environmental Remediation and Ecological Health, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
J Hazard Mater. 2024 Dec 5;480:135897. doi: 10.1016/j.jhazmat.2024.135897. Epub 2024 Sep 18.
Humankind are being exposed to a cocktail of chemicals, such as chemicals released from plastic food packaging. It is of great importance to evaluate the prevalence of plastic food packaging-derived chemicals pollution along the flow of food-human. We developed a robust and practical database of 2101 chemical features associated with plastic food packaging that combined data from three sources, 925 of which were acquired from non-target screening of chemical extracts from eight commonly used plastic food packaging materials. In this database, 625 features, especially half of the non-targets, were potential migrants who likely entered our bodies through dietary intake. Biomonitoring analysis of plastic chemical features in foodstuffs or human serum samples showed that approximately 78 % of the 2101 features were detectable and approximately half were non-targets. Of these, 17 plastic chemicals with high detection frequencies (DFs) in the human serum were confirmed to be functional chemical additives. Together, our work indicates that the number of plastic chemicals in our bodies could be far greater than previously recognized, and human exposure to plastic chemicals might pose a potential health risk.
人类正暴露在化学物质的“鸡尾酒”中，例如塑料食品包装释放的化学物质。评估食品-人类食物链中塑料食品包装衍生化学物质污染的流行程度非常重要。我们开发了一个强大且实用的数据库，其中包含与塑料食品包装相关的 2101 种化学特征，这些数据来自三个来源，其中 925 种是从八种常用塑料食品包装材料的化学提取物中进行非靶向筛选获得的。在这个数据库中，625 种特征，特别是其中一半的非靶向特征，很可能是通过饮食摄入进入我们体内的潜在迁移者。对食品或人血清样本中的塑料化学特征进行生物监测分析表明，在 2101 种特征中，约有 78%是可检测的，其中约一半是非靶向特征。在这些特征中，有 17 种在人血清中具有高检测频率（DF）的塑料化学物质被确认为功能性化学添加剂。总之，我们的工作表明，我们体内的塑料化学物质数量可能远远超过之前的认知，而人类接触塑料化学物质可能会带来潜在的健康风险。
