MD/PhD Program, University of Kentucky College of Medicine, Lexington, KY, USA; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA.
Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA.
J Neurol Sci. 2024 Nov 15;466:123232. doi: 10.1016/j.jns.2024.123232. Epub 2024 Sep 12.
We evaluated the relationship between baseline enlarged perivascular space (ePVS) burden and later cognitive decline.
83 community-dwelling, older adults (aged 56-86) completed three annual cognitive assessments that included the Clinical Dementia Rating (CDR®) Dementia Staging Instrument Sum of Boxes (CDR-SB) and composite measures of executive function and episodic memory. An MRI scan at baseline was used to count ePVS in the basal ganglia and centrum semiovale. Mixed effects models were run with ePVS as the predictor variable and cognitive measures as the dependent variable. Covariates included age, sex, education, cerebral small vessel disease (cSVD) risk factors, and cSVD neuroimaging biomarkers.
At baseline, high basal ganglia ePVS counts were associated with lower executive function scores and episodic memory scores. Moreover, baseline basal ganglia ePVS predicted worse longitudinal CDR-SB scores over the study period.
Basal ganglia ePVS burden is a promising biomarker for cSVD-related cognitive and functional decline.
我们评估了基线期血管周围间隙扩大（ePVS）负担与随后认知能力下降之间的关系。
83 名居住在社区的老年人（年龄 56-86 岁）完成了三次年度认知评估，其中包括临床痴呆评定量表（CDR®）痴呆分期工具总积分（CDR-SB）和执行功能以及情景记忆的综合测量。基线期的 MRI 扫描用于计算基底节和半卵圆中心的 ePVS。使用混合效应模型，以 ePVS 为预测变量，认知测量为因变量。协变量包括年龄、性别、教育、脑小血管疾病（cSVD）危险因素和 cSVD 神经影像学生物标志物。
基线时，基底节区 ePVS 计数较高与执行功能评分和情景记忆评分较低相关。此外，基线期基底节区 ePVS 可预测研究期间 CDR-SB 评分的纵向恶化。
基底节区 ePVS 负担是与 cSVD 相关的认知和功能下降的有前途的生物标志物。
