Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College, Beijing, China; State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China.
Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, and Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
Ecotoxicol Environ Saf. 2024 Oct 15;285:116987. doi: 10.1016/j.ecoenv.2024.116987. Epub 2024 Sep 18.
Studies about the combined effects of gaseous air pollutants and particulate matters are still rare.
This study was performed based on baseline survey of the Diverse Life-Course Cohort in the Beijing-Tianjin-Hebei (BTH) Region of North China to evaluate the association of long-term air pollutants with blood pressure and the combined effect of the air pollutants mixture among 32821 natural han population aged 20 years or above.
Three-year average exposure to air pollutants (PM, PM, PM, O, SO, NO, and CO) and PM components [black carbon (BC), ammonium (NH), nitrate (NO), sulfate (SO), and organic matter (OM)] of residential areas were calculated based on well-validated models. Generalized linear mixed models (GLMMs) were used to estimate the associations of air pollutants exposure with the systolic blood pressure (SBP), diastolic blood pressure (DBP), Mean arterial pressure (MAP), pulse pressure (PP) and prevalent hypertension. Quantile g-Computation and Bayesian Kernel Machine Regression (BKMR) were employed to assess the combined effect of the air pollutant mixture.
We found that long-term exposures of O, PM, and PM components were stably and strongly associated with elevated SBP, DBP, and MAP and prevalent hypertension. O increased SBP, DBP, and MAP at a similar extent, but with greater effects; while, PM and PM components had a greater impact on SBP than DBP, which increased PP simultaneously. In multi-pollutant models, the combined effects of the air pollutant mixture on blood pressure and prevalent hypertension was predominantly influenced by O, PM, and O, OM in different models, respectively. For example, O, PM contributed 57.25 %, 39.22 % of the positive combined effect of the air pollutant mixture on SBP; and O, OM positively contributed 70.00 %, 30.00 % on prevalent hypertension, respectively. There were interactions between O, CO, SO and PM components on hbp, SBP and PP.
The results showed positive associations of air pollutant mixtures with blood pressure, where O and PM (especially OM) might be primary contributors. There were interactions between gaseous air pollutants and PM components on blood pressure and prevalent hypertension.
关于气态空气污染物和颗粒物综合影响的研究仍然较少。
本研究基于华北京津冀地区多样化生命历程队列的基线调查，评估长期空气污染物与血压的关系，并评估 32821 名汉族自然人群中空气污染物混合物的综合效应。
根据经过良好验证的模型，计算了居住地区的三年平均空气污染物（PM、PM、PM、O、SO、NO 和 CO）和 PM 成分（黑碳（BC）、铵（NH）、硝酸盐（NO）、硫酸盐（SO）和有机物（OM））的暴露量。采用广义线性混合模型（GLMMs）估计空气污染物暴露与收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、脉压（PP）和高血压患病率之间的关系。采用分位数 g 计算和贝叶斯核机器回归（BKMR）评估空气污染物混合物的综合效应。
我们发现，O、PM 和 PM 成分的长期暴露与 SBP、DBP 和 MAP 的升高以及高血压患病率稳定且强烈相关。O 对 SBP、DBP 和 MAP 的影响相似，但影响更大；而 PM 和 PM 成分对 SBP 的影响大于 DBP，同时增加了 PP。在多污染物模型中，空气污染物混合物对血压和高血压患病率的综合影响主要受 O、PM 和不同模型中 O、OM 的影响。例如，O、PM 对 SBP 的空气污染物混合物的正综合效应分别贡献了 57.25%、39.22%；O、OM 分别对高血压患病率的正综合效应贡献了 70.00%、30.00%。O、CO、SO 和 PM 成分之间存在交互作用，影响 hbp、SBP 和 PP。
结果表明，空气污染物混合物与血压呈正相关，其中 O 和 PM（尤其是 OM）可能是主要贡献者。气态空气污染物和 PM 成分之间存在交互作用，影响血压和高血压患病率。
