Yang Fan, Zhang Guoxia, An Na, Dai Qianqian, Cho William, Shang Hongcai, Xing Yanwei
Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China.
Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, China; Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China.
Semin Cancer Biol. 2024 Nov;106-107:106-122. doi: 10.1016/j.semcancer.2024.09.003. Epub 2024 Sep 17.
With the prolonged survival of individuals with cancer, the emergence of cardiovascular diseases (CVD) induced by cancer treatment has become a significant concern, ranking as the second leading cause of death among cancer survivors. This review explores three distinct types of programmed cell death (PCD): ferroptosis, cuproptosis, and PANoptosis, focusing on their roles in chemotherapy-induced cardiotoxicity. While ferroptosis and cuproptosis are triggered by excess iron and copper (Cu), PANoptosis is an inflammatory PCD with features of pyroptosis, apoptosis, and necroptosis. Recent studies reveal intricate connections among these PCD types, emphasizing the interplay between cuproptosis and ferroptosis. Notably, the role of intracellular Cu in promoting ferroptosis through GPX4 is highlighted. Additionally, ROS-induced PANoptosis is influenced by ferroptosis and cuproptosis, suggesting a complex interrelationship. This review provides insights into the molecular mechanisms of these PCD modalities and their distinct contributions to chemotherapy-induced cardiotoxicity. Furthermore, we discuss the potential application of cardioprotective drugs in managing these PCD types. This comprehensive analysis aims to advance the understanding, diagnosis, and therapeutic strategies for cardiotoxicity associated with cancer treatment.
随着癌症患者生存期的延长，癌症治疗引起的心血管疾病（CVD）的出现已成为一个重大问题，是癌症幸存者中第二大死因。本综述探讨了三种不同类型的程序性细胞死亡（PCD）：铁死亡、铜死亡和PANoptosis，重点关注它们在化疗诱导的心脏毒性中的作用。虽然铁死亡和铜死亡分别由过量的铁和铜（Cu）触发，但PANoptosis是一种具有焦亡、凋亡和坏死性凋亡特征的炎症性PCD。最近的研究揭示了这些PCD类型之间的复杂联系，强调了铜死亡和铁死亡之间的相互作用。值得注意的是，强调了细胞内铜通过GPX4促进铁死亡的作用。此外，ROS诱导的PANoptosis受铁死亡和铜死亡的影响，表明存在复杂的相互关系。本综述深入探讨了这些PCD模式的分子机制及其对化疗诱导的心脏毒性的独特作用。此外，我们讨论了心脏保护药物在处理这些PCD类型中的潜在应用。这一全面分析旨在促进对癌症治疗相关心脏毒性的理解、诊断和治疗策略。
