Roberts Drucilla, Aisagbonhi Omonigho, Parast Mana M
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Trends Mol Med. 2024 Dec;30(12):1103-1112. doi: 10.1016/j.molmed.2024.08.002. Epub 2024 Sep 18.
Despite recent standardization of placental evaluation and establishment of criteria for diagnosis of major patterns of placental injury, placental pathological examination remains undervalued and under-utilized. The placenta can harbor a significant amount of information relevant to both the pregnant person and offspring. Placental pathology can also provide a significant context for pathophysiological study of adverse pregnancy outcomes, helping to optimally subcategorize the 'great obstetric syndromes' of pre-eclampsia (PE), spontaneous preterm birth (sPTB), and fetal growth restriction (FGR), and to identify causes of stillbirth. We hereby propose that placental evaluation should be incorporated into routine delivery of obstetric and neonatal care, and further suggest that its integration into clinical, translational, and basic research could significantly advance our understanding of pregnancy complications and adverse neonatal outcomes.
尽管最近胎盘评估实现了标准化，并建立了胎盘损伤主要模式的诊断标准，但胎盘病理检查仍未得到充分重视和利用。胎盘可能蕴含大量与孕妇和胎儿相关的信息。胎盘病理学还可为不良妊娠结局的病理生理研究提供重要背景，有助于对先兆子痫（PE）、自发性早产（sPTB）和胎儿生长受限（FGR）等“重大产科综合征”进行最佳分类，并确定死产原因。我们在此提议，胎盘评估应纳入产科和新生儿护理的常规流程，并进一步表明将其纳入临床、转化和基础研究可显著增进我们对妊娠并发症和不良新生儿结局的理解。
