Thurgood Giarman Ashley, Hays Hannah L, Badeti Jaahnavi, Rine Natalie I, Spiller Henry A, Zhu Motao, Smith Gary A
Center for Injury Research and Policy, The Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH, 43205, USA.
A.T. Still, University of Health Sciences, 5850 E. Still Circle, Mesa, AZ, 85206, USA.
Inj Epidemiol. 2024 Sep 19;11(1):51. doi: 10.1186/s40621-024-00536-y.
To investigate the characteristics and trends of therapeutic errors that occur outside of healthcare facilities involving diabetes medications reported to US poison centers.
National Poison Data System data from 2000 to 2021 were retrospectively analyzed.
There were 157,623 exposure cases of non-healthcare facility-related therapeutic errors associated with diabetes medications as the primary substance reported to US poison centers from 2000 to 2021. The rate of all therapeutic errors involving diabetes medications increased by 279.8% from 2000 to 2011, followed by a slower 15.0% increase to 2021. Half (50.1%) of the exposure cases were treated/evaluated and released and 44.1% did not receive treatment in a healthcare facility; however, 9.9% experienced a serious medical outcome, including 17 fatalities, and 1.0% were admitted to a critical care unit and 2.2% to a non-critical care unit. Insulin had the highest rates of therapeutic errors and serious medical outcomes, while sulfonylureas and insulin had the highest medical hospital admission rates. Metformin accounted for 59% (n = 10) of fatalities.
Although most cases of therapeutic errors involving diabetes medications had no or minimal clinical consequences, an important minority were associated with a serious medical outcome or medical hospital admission. Increased efforts to prevent therapeutic errors involving diabetes medications are warranted.
调查向美国毒物控制中心报告的、发生在医疗机构之外的糖尿病药物治疗错误的特征和趋势。
对2000年至2021年的国家毒物数据系统数据进行回顾性分析。
2000年至2021年期间，向美国毒物控制中心报告了157,623例与糖尿病药物作为主要物质相关的非医疗机构治疗错误暴露病例。从2000年到2011年，所有涉及糖尿病药物的治疗错误率增加了279.8%，随后到2021年增长较慢，为15.0%。一半（50.1%）的暴露病例接受了治疗/评估并出院，44.1%未在医疗机构接受治疗；然而，9.9%出现了严重的医疗后果，包括17例死亡，1.0%被收入重症监护病房，2.2%被收入非重症监护病房。胰岛素的治疗错误率和严重医疗后果率最高，而磺脲类药物和胰岛素的医院入院率最高。二甲双胍占死亡病例的59%（n = 10）。
虽然大多数涉及糖尿病药物的治疗错误病例没有或只有轻微的临床后果，但一小部分与严重的医疗后果或医院入院有关。有必要加大力度预防涉及糖尿病药物的治疗错误。
