雄激素和促性腺激素对青春期前大鼠睾丸发育的影响。
The effects of androgens and gonadotropins on testicular development in the prepubertal rat.
作者信息
Kennedy R I, Rawlings N C, Murphy B D
出版信息
Can J Comp Med. 1985 Jul;49(3):333-6.
Treatment of male rat pups from five to 34 days of age with dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, resulted in reduced testicular size at 35 days of age. This appeared to be due to decreased tubular diameters and reduced spermatocyte numbers, especially late pachytene cells in stages X to XIII. In rat pups treated with dihydrotestosterone or 5 alpha-androstane-3 alpha, 17 beta-diol, treatment with luteinizing hormone resulted in some restoration of tubular diameter and spermatocyte numbers. In 5 alpha-androstane-3 alpha, 17 beta-diol treated rat pups partial restoration of testes size resulted from follicle-stimulating hormone treatment, but tubular diameter and spermatocyte numbers were depressed. Single serum samples collected at 35 days of age were analysed for luteinizing and follicle-stimulating hormone concentrations. These data indicated that the effects of administered androgens were due primarily to depression of circulating gonadotropin concentrations but a direct inhibition at the level of the testis could not be ruled out.
对5至34日龄的雄性幼鼠用二氢睾酮或5α-雄烷-3α,17β-二醇进行处理，结果导致其在35日龄时睾丸体积减小。这似乎是由于曲细精管直径减小和精母细胞数量减少，尤其是X至XIII期的晚期粗线期细胞。在用二氢睾酮或5α-雄烷-3α,17β-二醇处理的幼鼠中，用促黄体生成素进行处理可使曲细精管直径和精母细胞数量有所恢复。在用5α-雄烷-3α,17β-二醇处理的幼鼠中，促卵泡激素处理使睾丸大小部分恢复，但曲细精管直径和精母细胞数量仍受到抑制。对35日龄时采集的单次血清样本进行促黄体生成素和促卵泡激素浓度分析。这些数据表明，给予雄激素的作用主要是由于循环促性腺激素浓度降低，但不能排除在睾丸水平存在直接抑制作用。
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