• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

高敏C反应蛋白（hs-CRP）水平与脂质及微量营养素之间的关联

Association Between High-Sensitivity C-Reactive Protein (hs-CRP) Levels With Lipids and Micronutrients.

作者信息

Krishnamurthy Hari K, Reddy Swarnkumar, Jayaraman Vasanth, Krishna Karthik, Song Qi, Wang Tianhao, Bei Kang, Rajasekaran John J

机构信息

Biomedical Engineering, Vibrant America LLC, San Carlos, USA.

出版信息

Cureus. 2024 Aug 20;16(8):e67268. doi: 10.7759/cureus.67268. eCollection 2024 Aug.

DOI:10.7759/cureus.67268
PMID:39301363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11411388/
Abstract

BACKGROUND AND AIMS

Elevated high-sensitivity C-reactive protein (hs-CRP) levels are associated with an increased risk of cardiovascular disease, indicating systemic inflammation. Abnormal lipid levels and deficiencies in certain vitamins and minerals could also contribute to elevated hs-CRP levels. By broadly looking at the cross-correlations between inflammatory, lipid, and micronutrient markers, we aim to highlight the key associations at the serological levels.

METHODS

A retrospective analysis was conducted on 1,014 free-living individuals who tested for cardiovascular and micronutrient panels along with hs-CRP at Vibrant America Clinical Laboratory.

RESULTS AND CONCLUSION

Based on parametric t-tests, significant variations between the sexes (Ma1) were observed for cholesterol, high-density lipoprotein (HDL), triglycerides, vitamin A, vitamin D3, serum copper, and valine. Pearson's correlation showed a high-significant positive correlation between hs-CRP and triglycerides, folate, serum copper, and manganese.

摘要

背景与目的

高敏C反应蛋白（hs-CRP）水平升高与心血管疾病风险增加相关，提示存在全身炎症。脂质水平异常以及某些维生素和矿物质缺乏也可能导致hs-CRP水平升高。通过广泛研究炎症、脂质和微量营养素标志物之间的相互关系，我们旨在突出血清学水平上的关键关联。

方法

对在活力美国临床实验室进行心血管和微量营养素检测以及hs-CRP检测的1014名自由生活个体进行回顾性分析。

结果与结论

基于参数t检验，观察到胆固醇、高密度脂蛋白（HDL）、甘油三酯、维生素A、维生素D3、血清铜和缬氨酸在性别之间存在显著差异（Ma1）。Pearson相关性分析显示hs-CRP与甘油三酯、叶酸、血清铜和锰之间存在高度显著的正相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/828b/11411388/692e83502653/cureus-0016-00000067268-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/828b/11411388/effe9bb9ad30/cureus-0016-00000067268-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/828b/11411388/692e83502653/cureus-0016-00000067268-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/828b/11411388/effe9bb9ad30/cureus-0016-00000067268-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/828b/11411388/692e83502653/cureus-0016-00000067268-i02.jpg

相似文献

1
Association Between High-Sensitivity C-Reactive Protein (hs-CRP) Levels With Lipids and Micronutrients.高敏C反应蛋白（hs-CRP）水平与脂质及微量营养素之间的关联
Cureus. 2024 Aug 20;16(8):e67268. doi: 10.7759/cureus.67268. eCollection 2024 Aug.
2
Assessment of Remnant Lipoprotein Cholesterol and Oxidized Low density Lipoprotein Associated with Low-grade Inflammation in Coronary Heart Disease Subjects of Young South Indian Population.评估南印度年轻人群冠心病患者的残余脂蛋白胆固醇和与低度炎症相关的氧化型低密度脂蛋白。
J Assoc Physicians India. 2022 Jun;70(6):11-12. doi: 10.5005/japi-11001-0009.
3
Total cholesterol-to-high-density lipoprotein cholesterol ratio predicts high-sensitivity C-reactive protein levels in Turkish children.总胆固醇与高密度脂蛋白胆固醇之比可预测土耳其儿童的高敏C反应蛋白水平。
J Clin Lipidol. 2015 Mar-Apr;9(2):195-200. doi: 10.1016/j.jacl.2014.12.010. Epub 2014 Dec 26.
4
Vitamin D status affects the relationship between lipid profile and high-sensitivity C-reactive protein.维生素D状态影响血脂谱与高敏C反应蛋白之间的关系。
Nutr Metab (Lond). 2020 Jul 14;17:57. doi: 10.1186/s12986-020-00455-x. eCollection 2020.
5
Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey.较高的膳食维生素D摄入量会影响血脂谱和超敏C反应蛋白浓度：基于美国国家健康与营养检查调查的横断面评估
Life (Basel). 2023 Feb 19;13(2):581. doi: 10.3390/life13020581.
6
Correlations between Body Mass Index, Plasma High-Sensitivity C-Reactive Protein and Lipids in Patients with Schizophrenia.精神分裂症患者的体重指数、血浆高敏 C 反应蛋白与血脂的相关性。
Psychiatr Q. 2019 Mar;90(1):101-110. doi: 10.1007/s11126-018-9606-3.
7
Association of Apolipoprotein E (APOE) Polymorphisms With Serological Lipid and Inflammatory Markers.载脂蛋白E（APOE）基因多态性与血清脂质及炎症标志物的关联
Cureus. 2024 May 20;16(5):e60721. doi: 10.7759/cureus.60721. eCollection 2024 May.
8
The predictive value of the hs-CRP/HDL-C ratio, an inflammation-lipid composite marker, for cardiovascular disease in middle-aged and elderly people: evidence from a large national cohort study.hs-CRP/HDL-C 比值作为炎症-脂质复合标志物对中老年人心血管疾病的预测价值：来自大型全国队列研究的证据。
Lipids Health Dis. 2024 Mar 1;23(1):66. doi: 10.1186/s12944-024-02055-7.
9
Low-Density Lipoprotein Cholesterol Is Not a Major Determinant of High-Sensitivity C-Reactive Protein Levels in People Without Known Diabetes Mellitus.低密度脂蛋白胆固醇并非无糖尿病史人群中高敏C反应蛋白水平的主要决定因素。
Metab Syndr Relat Disord. 2023 Dec;21(10):567-572. doi: 10.1089/met.2023.0061. Epub 2023 Sep 28.
10
Association of high-sensitivity C-reactive protein with cardiometabolic risk factors and micronutrient deficiencies in adults of Ouagadougou, Burkina Faso.高敏 C 反应蛋白与布基纳法索瓦加杜古成年人的心血管代谢危险因素和微量营养素缺乏的关系。
Br J Nutr. 2013 Apr 14;109(7):1266-75. doi: 10.1017/S0007114512003182. Epub 2012 Aug 23.

引用本文的文献

1
Prospective Associations of Dietary Antioxidant Vitamin Intake and 8-Year Risk of Elevated Serum -Reactive Protein Levels.膳食抗氧化维生素摄入量与血清反应蛋白水平升高的8年风险的前瞻性关联。
Nutrients. 2025 Mar 14;17(6):1020. doi: 10.3390/nu17061020.

本文引用的文献

1
Circulating Copper Is Associated with Inflammatory Biomarkers in Greek Older Adults with Osteoarthritis.循环铜与希腊老年骨关节炎患者的炎症生物标志物相关。
Biol Trace Elem Res. 2024 May;202(5):1866-1877. doi: 10.1007/s12011-023-03801-1. Epub 2023 Aug 22.
2
Preliminary Study on the Association of Serum Branched-Chain Amino Acids With Lipid and Hepatic Markers.血清支链氨基酸与血脂及肝脏标志物相关性的初步研究
Cardiol Res. 2023 Jun;14(3):167-175. doi: 10.14740/cr1454. Epub 2023 May 26.
3
Higher Dietary Vitamin D Intake Influences the Lipid Profile and hs-CRP Concentrations: Cross-Sectional Assessment Based on The National Health and Nutrition Examination Survey.
较高的膳食维生素D摄入量会影响血脂谱和超敏C反应蛋白浓度：基于美国国家健康与营养检查调查的横断面评估
Life (Basel). 2023 Feb 19;13(2):581. doi: 10.3390/life13020581.
4
Circulating Level of Blood Iron and Copper Associated with Inflammation and Disease Activity of Rheumatoid Arthritis.血液中铁和铜的循环水平与类风湿关节炎的炎症及疾病活动度相关。
Biol Trace Elem Res. 2023 Jan;201(1):90-97. doi: 10.1007/s12011-022-03148-z. Epub 2022 Mar 28.
5
The Role of Minerals in the Optimal Functioning of the Immune System.矿物质在免疫系统最佳功能中的作用。
Nutrients. 2022 Feb 2;14(3):644. doi: 10.3390/nu14030644.
6
Effect of Micronutrients on Thyroid Parameters.微量营养素对甲状腺参数的影响。
J Thyroid Res. 2021 Sep 28;2021:1865483. doi: 10.1155/2021/1865483. eCollection 2021.
7
The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.叶酸补充对促炎介质的影响：随机对照试验的系统评价和剂量反应荟萃分析。
Clin Ther. 2021 Dec;43(12):e346-e363. doi: 10.1016/j.clinthera.2021.10.002. Epub 2021 Nov 29.
8
The association between high sensitivity C-reactive protein and micronutrient levels: A cross-sectional analysis based on a laboratory database.高敏C反应蛋白与微量营养素水平之间的关联：基于实验室数据库的横断面分析。
Clin Nutr ESPEN. 2019 Oct;33:283-289. doi: 10.1016/j.clnesp.2019.06.011. Epub 2019 Jul 3.
9
Effects of folic acid supplementation on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials.叶酸补充对 C 反应蛋白的影响：一项随机对照试验的系统评价和荟萃分析。
Nutr Metab Cardiovasc Dis. 2019 May;29(5):432-439. doi: 10.1016/j.numecd.2018.11.006. Epub 2018 Dec 6.
10
The Role of Vitamin E in the Treatment of NAFLD.维生素E在非酒精性脂肪性肝病治疗中的作用。
Diseases. 2018 Sep 24;6(4):86. doi: 10.3390/diseases6040086.