Nelson LaRon E, Wilton Leo, Whitfield Darren L, Williams Geoffrey C, Mayer Kenneth H, Komárek Arnošt, Boyd Donte T, Beauchamp Geetha, Fields Sheldon D, Wheeler Darrell P
School of Nursing, Yale University, 400 West Campus Drive, New Haven, CT, 06477, USA.
Unity Health Toronto, St. Michael's Hospital, Li Ka Shing Knowledge Institute, MAP Center for Urban Health Solutions, Toronto, ON, Canada.
Sex Res Social Policy. 2022 Sep;19(3):1365-1382. doi: 10.1007/s13178-022-00687-x. Epub 2022 Jan 26.
There are few culturally informed, theory-driven evidence-based strategies to support PrEP use among Black MSM. This paper describes the theoretical foundation and conceptual development of C4 to support the prevention of HIV and other STIs.
C4 integrates self-determination theory with comprehensive risk counseling and services using an integrative anti-racism lens. C4 was implemented in a 52-week HIV prevention demonstration project to facilitate PrEP use and adherence among Black MSM (=225) in three US cities from 2014-2017.
PrEP use was 79%, with 91% of PrEP users starting within 30-days. 12-month retention in C4 was 92%. Care coordination encounters focused primarily on clients' needs related to PrEP adherence (43%) and sexual health (19%). Over the 12-month period, a substantial proportion of the men made progress towards their PrEP adherence goals at the 8-week (83%), 26-week (75%) and 52-week (81%) study visits.
C4 is a multi-level, multi-component intervention that dually targets individual-level motivations and capacities of Black MSM and the healthcare facility-level attitudes, behaviors and processes that characterize the climates where Black MSM receive services.
Public health policy efforts to scale-up PrEP may consider C4 as a tool to optimize the use of PrEP and PrEP program retention with Black MSM. C4 is also a tool for healthcare facilities to transform their models of service delivery towards improving the implementation PrEP services, including ensuring racial equity in the prevention impact of novel PrEP formulations such as long-acting injectable and potential future long-acting oral regimens.
几乎没有基于文化、理论驱动且以证据为基础的策略来支持黑人男男性行为者使用暴露前预防(PrEP)。本文描述了C4的理论基础和概念发展,以支持预防艾滋病毒和其他性传播感染。
C4将自我决定理论与全面的风险咨询及服务相结合,采用综合的反种族主义视角。2014年至2017年期间,C4在一个为期52周的艾滋病毒预防示范项目中实施,以促进美国三个城市的225名黑人男男性行为者使用PrEP并坚持用药。
PrEP使用率为79%,91%的PrEP使用者在30天内开始用药。C4项目12个月的留存率为92%。护理协调工作主要集中在与PrEP坚持用药(43%)和性健康(19%)相关的客户需求上。在12个月期间,很大一部分男性在第8周(83%)、第26周(75%)和第52周(81%)的研究访视中朝着他们的PrEP坚持用药目标取得了进展。
C4是一种多层次、多成分的干预措施,它既针对黑人男男性行为者的个人层面动机和能力,也针对医疗保健机构层面的态度、行为和流程,这些态度、行为和流程是黑人男男性行为者接受服务的环境特征。
扩大PrEP使用的公共卫生政策努力可将C4视为一种工具,以优化PrEP的使用以及与黑人男男性行为者的PrEP项目留存率。C4也是医疗保健机构转变其服务提供模式的工具,以改善PrEP服务的实施,包括确保在长效注射等新型PrEP制剂以及未来可能的长效口服方案的预防效果方面实现种族公平。