Dong Jiaxing, Jiang Wanju, Zhang Wenjia, Guo Taohua, Yang Yucheng, Jiang Xiaohua, Zheng Liang, Du Tao
Department of Gastrointestinal Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Respiratory Medicine, Shanghai Tenth Peoples Hospital, Tongji University, Shanghai, China.
Front Oncol. 2024 Sep 5;14:1388610. doi: 10.3389/fonc.2024.1388610. eCollection 2024.
The recent hemoglobin, albumin, lymphocyte, and platelet (HALP) scores, combined with various clinically available indicators, can comprehensively evaluate the nutritional and immune status of patients. Some observational studies have found a positive correlation between HALP score and cancer prognosis, but the clinical application of HALP score has raised concerns due to the presence of confounding factors. The aim of this study is to explore the relationship between HALP score and long-term mortality in cancer patients.
We extracted 3832 cancer patients with complete baseline information from the National Health and Nutrition Examination Survey (NHANES). The COX regressions and restricted cubic spline (RCS) curves were used to explore the nonlinear relationship between HALP score and long-term mortality risk in cancer patients. Kaplan-Meier (K-M) curve was conducted to evaluate the impact of HALP score on long-term mortality risk. Additionally, subgroup analysis was conducted to verify the stability of the above results.
We divided participants into 4 groups based on HALP score, and the COX regression results showed that risk of long-term mortality tended to be lower in cancer patients with high HALP scores. Meanwhile, the RCS curves showed that there was a nonlinear association. The results remained stable in subgroup analyses and in breast cancer, colorectal cancer, cervix and uterus cancer, melanoma, prostate cancer and skin cancer.
HALP score were independently associated with the risk of long-term mortality in cancer patients, and there is also a non-linear association. This will provide new perspectives on clinical and nutritional interventions for cancer patients.
近期的血红蛋白、白蛋白、淋巴细胞和血小板（HALP）评分与各种临床可用指标相结合，可全面评估患者的营养和免疫状况。一些观察性研究发现HALP评分与癌症预后之间存在正相关，但由于存在混杂因素，HALP评分的临床应用引发了关注。本研究的目的是探讨HALP评分与癌症患者长期死亡率之间的关系。
我们从国家健康与营养检查调查（NHANES）中提取了3832例具有完整基线信息的癌症患者。使用COX回归和受限立方样条（RCS）曲线来探讨HALP评分与癌症患者长期死亡风险之间的非线性关系。采用Kaplan-Meier（K-M）曲线评估HALP评分对长期死亡风险的影响。此外，进行亚组分析以验证上述结果的稳定性。
我们根据HALP评分将参与者分为4组，COX回归结果显示，HALP评分高的癌症患者长期死亡风险往往较低。同时，RCS曲线显示存在非线性关联。在亚组分析以及乳腺癌、结直肠癌、宫颈癌、黑色素瘤、前列腺癌和皮肤癌中，结果保持稳定。
HALP评分与癌症患者的长期死亡风险独立相关，且存在非线性关联。这将为癌症患者的临床和营养干预提供新的视角。
