Voelkel N F, Morganroth M, Feddersen O C
Chest. 1985 Oct;88(4 Suppl):245S-248S. doi: 10.1378/chest.88.4_supplement.245s.
Hypoxic vasoconstriction is important for lung ventilation/perfusion matching. The mechanism of hypoxic vasoconstriction remains elusive. Arachidonic acid is released from hypoxic tissues; possibly vasoconstricting arachidonate metabolites are involved in hypoxic pulmonary vasoconstriction. Data are presented that consider (a) lipoxygenase product(s) as "local," which could be involved in the hypoxia induced pulmonary vasoconstriction.
缺氧性血管收缩对肺通气/灌注匹配很重要。缺氧性血管收缩的机制仍不清楚。花生四烯酸从缺氧组织中释放；可能是血管收缩性花生四烯酸代谢产物参与了缺氧性肺血管收缩。现有数据表明，（a）脂氧合酶产物作为“局部”物质，可能参与缺氧诱导的肺血管收缩。
