School of Mathematics and Statistics, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China.
Mol Med Rep. 2024 Nov;30(5). doi: 10.3892/mmr.2024.13332. Epub 2024 Sep 20.
Cardiac hypertrophy results from the heart reacting and adapting to various pathological stimuli and its persistent development is a major contributing factor to heart failure. However, the molecular mechanisms of cardiac hypertrophy remain unclear. Small GTPases in the Ras, Rho, Rab, Arf and Ran subfamilies exhibit GTPase activity and play crucial roles in regulating various cellular responses. Previous studies have shown that Ras, Rho and Rab are closely linked to cardiac hypertrophy and that their overexpression can induce cardiac hypertrophy. Here, we review the functions of small GTPases in cardiac hypertrophy and provide additional insights and references for the prevention and treatment of cardiac hypertrophy.
心肌肥厚是心脏对各种病理性刺激的反应和适应，其持续发展是心力衰竭的主要致病因素。然而，心肌肥厚的分子机制尚不清楚。Ras、Rho、Rab、Arf 和 Ran 亚家族中的小 GTP 酶具有 GTP 酶活性，在调节各种细胞反应中发挥着重要作用。先前的研究表明，Ras、Rho 和 Rab 与心肌肥厚密切相关，其过度表达可诱导心肌肥厚。本文就小 GTP 酶在心肌肥厚中的作用进行综述，为心肌肥厚的防治提供新的思路和参考。
