Folia Parasitol (Praha). 2024 Sep 10;71:2024.017. doi: 10.14411/fp.2024.016.
Toxoplasmosis is caused by Toxoplasma gondii (Nicolle et Manceaux, 1908), a coccidian protist (Apicomplexa). It has a strong predilection for infecting the central nervous system. Researchers have therefore investigated its association with several neurological and psychiatric disorders, including Alzheimer's disease, attention-deficit hyperactivity disorder, autism, bipolar disorder, cerebral palsy, depression, Guillain-Barre syndrome, multiple sclerosis, obsessive compulsive disorder, Parkinson's disease, personality disorders, and schizophrenia. Among these disorders the strongest evidence for a role of T. gondii exists for psychosis in general and schizophrenia in particular. This paper reviews the origins of this association, briefly summarises the current evidence in support, and discusses future research strategies.
弓形虫病是由刚地弓形虫（Nicolle et Manceaux，1908）引起的，刚地弓形虫是一种肉足亚门顶复动物（孢子虫纲）。它强烈倾向于感染中枢神经系统。因此，研究人员研究了它与几种神经和精神疾病的关联，包括阿尔茨海默病、注意力缺陷多动障碍、自闭症、双相情感障碍、脑瘫、抑郁症、格林-巴利综合征、多发性硬化症、强迫症、帕金森病、人格障碍和精神分裂症。在这些疾病中，刚地弓形虫与一般精神病特别是精神分裂症之间存在最强的关联证据。本文回顾了这种关联的起源，简要总结了目前支持的证据，并讨论了未来的研究策略。
