桥本甲状腺炎患者全身炎症标志物的评估。
Evaluation of systemic inflammation markers in patients with Hashimoto's thyroiditis.
机构信息
Firat University School of Medicine, Department of General Surgery, Elazig, Turkey.
Health Sciences University, Elazig Fethi Sekin City Hospital, Department of Radiology, Elazig, Turkey.
出版信息
J Int Med Res. 2024 Sep;52(9):3000605241280049. doi: 10.1177/03000605241280049.
OBJECTIVE
To investigate markers of systemic inflammation and the effect of thyroid dysfunction on these parameters in patients with Hashimoto's thyroiditis (HT).
METHODS
Patients with HT and volunteer healthy individuals admitted to the general surgery outpatient clinic between January 2020 and June 2023 were enrolled into the study. Patients with HT were divided into euthyroid, hypothyroid, and hyperthyroid subgroups. All participant data were retrospectively extracted from the hospital database.
RESULTS
A total of 268 patients (euthyroid, = 131; hypothyroid, = 83; and hyperthyroid, = 54) and 124 controls were included. The platelet-to-lymphocyte ratio was lower in the euthyroid group versus control group, and the neutrophil-to-lymphocyte ratio was lower in controls than the three patient subgroups. Euthyroid and hypothyroid patients with HT exhibited a higher systemic inflammation index than the control group. The pan-immune inflammation index was lower in controls than in euthyroid, hypothyroid, and hyperthyroid patients with HT. In patients with HT, inflammation markers did not significantly differ between subgroups.
CONCLUSIONS
Markers of systemic inflammation provide meaningful and reliable information in patients with HT, but do not differentiate between euthyroid, hypothyroid, or hyperthyroid patients.
目的
研究桥本甲状腺炎（HT）患者的系统性炎症标志物以及甲状腺功能障碍对这些参数的影响。
方法
本研究纳入了 2020 年 1 月至 2023 年 6 月间在普外科门诊就诊的 HT 患者和志愿健康个体。将 HT 患者分为甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进亚组。所有参与者的数据均从医院数据库中回顾性提取。
结果
共纳入 268 例患者（甲状腺功能正常组=131 例；甲状腺功能减退组=83 例；甲状腺功能亢进组=54 例）和 124 名对照。与对照组相比，甲状腺功能正常组的血小板与淋巴细胞比值较低，而中性粒细胞与淋巴细胞比值则较低。甲状腺功能正常和甲状腺功能减退的 HT 患者的全身炎症指数均高于对照组。与甲状腺功能正常、甲状腺功能减退和甲状腺功能亢进的 HT 患者相比，对照组的全免疫炎症指数较低。在 HT 患者中，各亚组之间的炎症标志物无显著差异。
结论
全身炎症标志物在 HT 患者中提供了有意义且可靠的信息，但不能区分甲状腺功能正常、甲状腺功能减退或甲状腺功能亢进的患者。
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