桥本甲状腺炎和非免疫性甲状腺功能减退症中血常规衍生炎症指标的综合评估

A COMPREHENSIVE EVALUATION OF HEMOGRAM-DERIVED INFLAMMATORY INDICES IN HASHIMOTO THYROIDITIS AND NON-IMMUNOGENIC HYPOTHYROIDISM.

作者信息

Erinc O, Yesilyurt S, Senat A

机构信息

Taksim Training and Research Hospital - Internal Medicine, Katip Mustafa Çelebi, Sıraselviler Cd. No:48, 34433 Istanbul, Turkey.

Taksim Training and Research Hospital - Clinical Biochemistry, Istanbul, Turkey.

出版信息

Acta Endocrinol (Buchar). 2023 Oct-Dec;19(4):435-440. doi: 10.4183/aeb.2023.435. Epub 2024 Jun 24.

DOI:10.4183/aeb.2023.435

PMID:38933249

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11197836/

Abstract

OBJECTIVES

The objective of this study was to evaluate the Systemic Inflammation Index (SII), Platelet to Lymphocyte Ratio (PLR), and Neutrophil to Lymphocyte Ratio (NLR) in HT and NIH, as well as their diagnostic value to predict the presence of inflammation.

SUBJECTS AND METHODS

The study included 505 patients, including 190 healthy controls, 166 euthyroid Hashimoto's thyroiditis (HT), 91 hypothyroid HT, and 58 non- immunogenic hypothyroidism (NIH) patients. The records of the patients in each group were reviewed retrospectively.

RESULTS

In terms of SII, there was a significant difference between the control and patient groups (p<0.001). PLR and NLR values were also found to be significantly higher in the patient group (p<0.001 and p=0.007, respectively). When euthyroid HT, hypothyroid HT, and NIH subgroups were compared to the control group, there was a significant difference in SII, PLR (for all p<0.001), but not in NLR (p=0.059). SII, PLR, and NLR were not different between the subgroups (p=0.595, p=0.861, and p=0.777, respectively).

CONCLUSIONS

It was found that the PLR, NLR, and SII indices were higher in Hashimoto's thyroiditis and non-immunogenic hypothyroidism. Of these indices, SII was the most powerful marker to predict the presence of inflammation.

摘要

目的

本研究的目的是评估桥本甲状腺炎（HT）和非免疫性甲状腺功能减退症（NIH）中的全身炎症指数（SII）、血小板与淋巴细胞比值（PLR）以及中性粒细胞与淋巴细胞比值（NLR），及其预测炎症存在的诊断价值。

对象与方法

该研究纳入505例患者，包括190例健康对照、166例甲状腺功能正常的桥本甲状腺炎（HT）患者、91例甲状腺功能减退的HT患者以及58例非免疫性甲状腺功能减退症（NIH）患者。对每组患者的记录进行回顾性分析。

结果

在SII方面，对照组与患者组之间存在显著差异（p<0.001）。还发现患者组的PLR和NLR值也显著更高（分别为p<0.001和p=0.007）。当将甲状腺功能正常的HT、甲状腺功能减退的HT和NIH亚组与对照组进行比较时，SII、PLR存在显著差异（所有p<0.001），但NLR无显著差异（p=0.059）。各亚组之间的SII、PLR和NLR无差异（分别为p=0.595、p=0.861和p=0.777）。