致癌突变 p53 通过氧化应激依赖性诱导线粒体凋亡使非小细胞肺癌细胞对蛋白酶体抑制剂敏感。
Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis.
机构信息
Department of Medicine, Keck School of Medicine of USC, USC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California.
Philips Institute for Oral Health Research, VCU School of Dentistry, Virginia Commonwealth University, Richmond, Virginia.
出版信息
Cancer Res Commun. 2024 Oct 1;4(10):2685-2698. doi: 10.1158/2767-9764.CRC-23-0637.
NSCLC is the leading cause of cancer death due, in part, to a lack of active therapies in advanced disease. We demonstrate that combination therapy with a proteasome inhibitor, BH3-mimetic, and chemotherapy is an active precision therapy in NSCLC cells and tumors expressing Onc-p53 alleles.
非小细胞肺癌是癌症死亡的主要原因，部分原因是晚期疾病缺乏有效的治疗方法。我们证明，蛋白酶体抑制剂、BH3 模拟物和化疗联合治疗在表达 Onc-p53 等位基因的非小细胞肺癌细胞和肿瘤中是一种有效的精准治疗方法。
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