• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

干扰素非依赖性干扰：干扰素刺激基因的干扰素非依赖性诱导及其在细胞固有免疫中的作用。

Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity.

机构信息

Emerging Viral Pathogens Laboratory, Centre for Infectious Disease Research, Indian Institute of Science, Bengaluru, India.

Microbiology & Cell Biology Department, Biological Sciences Division, Indian Institute of Science, Bengaluru, India.

出版信息

mBio. 2024 Oct 16;15(10):e0258224. doi: 10.1128/mbio.02582-24. Epub 2024 Sep 20.

DOI:10.1128/mbio.02582-24
PMID:39302126
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11481898/
Abstract

Interferons (IFNs) are multifaceted proteins that play pivotal roles in orchestrating robust antiviral immune responses and modulating the intricate landscape of host immunity. The major signaling pathway activated by IFNs is the JAK/STAT (Janus kinase/signal transducer and activator of transcription) pathway, which leads to the transcription of a battery of genes, collectively known as IFN-stimulated genes (ISGs). While the well-established role of IFNs in coordinating the innate immune response against viral infections is widely acknowledged, recent years have provided a more distinct comprehension of the functional significance attributed to non-canonical, IFN-independent induction of ISGs. In this review, we summarize the non-conventional signaling pathways of ISG induction. These alternative pathways offer new avenues for developing antiviral strategies or immunomodulation in various diseases.

摘要

干扰素（IFNs）是一种多功能蛋白，在协调强大的抗病毒免疫反应和调节宿主免疫的复杂景观方面发挥着关键作用。IFNs 激活的主要信号通路是 JAK/STAT（Janus 激酶/信号转导和转录激活因子）通路，该通路导致一组基因的转录，统称为干扰素刺激基因（ISGs）。虽然 IFN 在协调针对病毒感染的先天免疫反应中的作用已得到广泛认可，但近年来人们对非经典、IFN 非依赖性诱导 ISGs 的功能意义有了更清晰的认识。在这篇综述中，我们总结了 ISG 诱导的非传统信号通路。这些替代途径为开发各种疾病的抗病毒策略或免疫调节提供了新的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0292/11481898/f0281ee202b2/mbio.02582-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0292/11481898/e43809ee8dd9/mbio.02582-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0292/11481898/f0281ee202b2/mbio.02582-24.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0292/11481898/e43809ee8dd9/mbio.02582-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0292/11481898/f0281ee202b2/mbio.02582-24.f002.jpg

相似文献

1
Interference without interferon: interferon-independent induction of interferon-stimulated genes and its role in cellular innate immunity.干扰素非依赖性干扰：干扰素刺激基因的干扰素非依赖性诱导及其在细胞固有免疫中的作用。
mBio. 2024 Oct 16;15(10):e0258224. doi: 10.1128/mbio.02582-24. Epub 2024 Sep 20.
2
The Molecular Basis of Viral Inhibition of IRF- and STAT-Dependent Immune Responses.病毒抑制 IRF 和 STAT 依赖性免疫反应的分子基础。
Front Immunol. 2019 Jan 8;9:3086. doi: 10.3389/fimmu.2018.03086. eCollection 2018.
3
Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity.单纯疱疹病毒 1 UL36USP 拮抗 I 型干扰素介导的抗病毒先天免疫。
J Virol. 2018 Sep 12;92(19). doi: 10.1128/JVI.01161-18. Print 2018 Oct 1.
4
Interferon-stimulated genes: a complex web of host defenses.干扰素刺激基因：宿主防御的复杂网络。
Annu Rev Immunol. 2014;32:513-45. doi: 10.1146/annurev-immunol-032713-120231. Epub 2014 Feb 6.
5
MDA5 against enteric viruses through induction of interferon-like response partially via the JAK-STAT cascade.MDA5 通过诱导干扰素样反应部分通过 JAK-STAT 级联对抗肠道病毒。
Antiviral Res. 2020 Apr;176:104743. doi: 10.1016/j.antiviral.2020.104743. Epub 2020 Feb 10.
6
Pseudorabies Virus Inhibits Type I and Type III Interferon-Induced Signaling via Proteasomal Degradation of Janus Kinases.伪狂犬病毒通过泛素蛋白酶体途径降解 Janus 激酶抑制 I 型和 III 型干扰素诱导的信号通路。
J Virol. 2021 Sep 27;95(20):e0079321. doi: 10.1128/JVI.00793-21. Epub 2021 Aug 11.
7
Enterovirus 2A Cleavage of the YTHDF mA Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling.肠道病毒 2A 对 YTHDF mA 读者的切割涉及 YTHDF3 作为 I 型干扰素驱动的 JAK/STAT 信号的中介。
mBio. 2021 Apr 13;12(2):e00116-21. doi: 10.1128/mBio.00116-21.
8
Transcriptional Regulation of Antiviral Interferon-Stimulated Genes.抗病毒干扰素刺激基因的转录调控
Trends Microbiol. 2017 Jul;25(7):573-584. doi: 10.1016/j.tim.2017.01.001. Epub 2017 Jan 27.
9
Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway.口疮病毒抑制干扰素刺激基因的表达，并调节 JAK/STAT 信号通路。
Virus Res. 2015 Oct 2;208:180-8. doi: 10.1016/j.virusres.2015.06.014. Epub 2015 Jun 22.
10
Interplay between Janus Kinase/Signal Transducer and Activator of Transcription Signaling Activated by Type I Interferons and Viral Antagonism.I型干扰素激活的Janus激酶/信号转导子和转录激活因子信号通路与病毒拮抗作用之间的相互作用
Front Immunol. 2017 Dec 11;8:1758. doi: 10.3389/fimmu.2017.01758. eCollection 2017.

引用本文的文献

1
Identification of childhood-onset lupus nephritis through integrative bioinformatics: otoferlin as a novel biomarker.通过整合生物信息学鉴定儿童期起病的狼疮性肾炎： otoferlin作为一种新型生物标志物
Pediatr Res. 2025 Aug 11. doi: 10.1038/s41390-025-04171-1.
2
Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus.单细胞解剖揭示SFRP2⁺成纤维细胞放大口腔扁平苔藓中的炎症反应。
Front Immunol. 2025 Jun 12;16:1553963. doi: 10.3389/fimmu.2025.1553963. eCollection 2025.
3
The intestinal interferon system and specialized enterocytes as putative drivers of HIV latency.
肠道干扰素系统和特化肠上皮细胞作为HIV潜伏的潜在驱动因素。
Front Immunol. 2025 May 14;16:1589752. doi: 10.3389/fimmu.2025.1589752. eCollection 2025.
4
Anthraquinone-2-Carboxylic Acid Is a Potential Antiviral Candidate Against Influenza Viruses In Vitro and In Vivo.蒽醌-2-羧酸是一种在体外和体内对流感病毒具有潜在抗病毒活性的候选药物。
Viruses. 2025 Apr 27;17(5):628. doi: 10.3390/v17050628.
5
Effects of Exposure to Different Types of Microplastics on the Growth and Development of Tadpoles.暴露于不同类型微塑料对蝌蚪生长发育的影响。
Toxics. 2025 Feb 26;13(3):165. doi: 10.3390/toxics13030165.
6
Regulation of epithelial growth factor receptors by the oncoprotein E5 during the HPV16 differentiation-dependent life cycle.人乳头瘤病毒16型分化依赖性生活周期中癌蛋白E5对上皮生长因子受体的调控
Tumour Virus Res. 2025 Mar 7;19:200315. doi: 10.1016/j.tvr.2025.200315.
7
Identification of interferon-stimulated response elements (ISREs) in canines.犬类中干扰素刺激反应元件（ISREs）的鉴定。
BMC Vet Res. 2025 Mar 1;21(1):128. doi: 10.1186/s12917-025-04577-3.
8
Examining the feasibility of replacing ORF3a with fluorescent genes to construct SARS-CoV-2 reporter viruses.研究用荧光基因替换开放阅读框3a（ORF3a）以构建严重急性呼吸综合征冠状病毒2（SARS-CoV-2）报告病毒的可行性。
J Gen Virol. 2025 Feb;106(2). doi: 10.1099/jgv.0.002072.
9
. Honey Exerts Antiviral Effect Against Influenza A Virus Infection Through Mitochondrial Stress-Mediated Enhancement of Innate Immunity.蜂蜜通过线粒体应激介导的先天免疫增强对甲型流感病毒感染发挥抗病毒作用。
Antioxidants (Basel). 2025 Jan 9;14(1):71. doi: 10.3390/antiox14010071.