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单养幼鱼会加速早期生长，但会延长非洲蓝鳃鱼的成年寿命。

Single housing of juveniles accelerates early-stage growth but extends adult lifespan in African turquoise killifish.

机构信息

Laboratory for Molecular Biology of Aging, RIKEN Center for Biosystems Dynamics Research (BDR), Hyogo, Japan.

Department of Neuroscience of Disease, Brain Research Institute, Niigata University, Niigata, Japan.

出版信息

Aging (Albany NY). 2024 Sep 16;16(18):12443-12472. doi: 10.18632/aging.206111.

DOI:10.18632/aging.206111
PMID:39302208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11466477/
Abstract

Within the same species, individuals exhibiting faster growth tend to have shorter lifespans, even if their fast growth arises from early-life pharmacological interventions. However, in vertebrates, the impact of the early-life environment on the growth rate and lifespan has not been fully elucidated. In this study, by utilizing the short-lived African turquoise killifish, which is suitable for a comprehensive life-stage analysis in a brief timeframe, we explored the effects of housing density during the juvenile stage on holistic life traits. As a result, we found that lower housing densities resulted in faster growth, but led to longer adult lifespan, which was contrary to the common notion. Furthermore, the single-housed adult fish displayed a longer egg-laying period than did their group-housed counterparts. Our transcriptome analysis also demonstrated that, in terms of internal transcriptional programs, the life stage progression and aging process of single-housed fish were slower than those of group-housed fish. Collectively, our results suggest that sharing housing with others in early life might influence whole-life attributes, potentially leading to specific life history traits beyond the typical relationship between the growth rate and lifespan.

摘要

在同一物种中，生长速度较快的个体往往寿命较短，即使它们的快速生长是由于早期的药物干预。然而，在脊椎动物中，早期环境对生长速度和寿命的影响尚未完全阐明。在这项研究中，我们利用寿命较短的非洲绿松石虾虎鱼作为研究对象，这种鱼适合在短时间内进行全面的生命阶段分析，以探讨幼年阶段的住房密度对整体生命特征的影响。结果表明，较低的住房密度会导致生长速度加快，但会导致成年寿命延长，这与普遍观点相反。此外，独居的成年鱼比群居的成年鱼产卵期更长。我们的转录组分析还表明，就内部转录程序而言，独居鱼的生命阶段进展和衰老过程比群居鱼慢。总的来说，我们的研究结果表明，早期与他人共同居住可能会影响终生属性，可能会导致特定的生活史特征，超出了生长速度和寿命之间的典型关系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/c5a0eae3c91d/aging-16-206111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/34369bc6b99b/aging-16-206111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/d4468bdee18b/aging-16-206111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/89eb6e990314/aging-16-206111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/3f76731e1c93/aging-16-206111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/16cd447227b7/aging-16-206111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/c6531a094b04/aging-16-206111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/c5a0eae3c91d/aging-16-206111-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/34369bc6b99b/aging-16-206111-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/d4468bdee18b/aging-16-206111-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/89eb6e990314/aging-16-206111-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/3f76731e1c93/aging-16-206111-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/16cd447227b7/aging-16-206111-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/c6531a094b04/aging-16-206111-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/052e/11466477/c5a0eae3c91d/aging-16-206111-g007.jpg

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