Mazzucchi A, Visintini D, Magnani G, Cattelani R, Parma M
Epilepsia. 1985 Sep-Oct;26(5):379-90. doi: 10.1111/j.1528-1157.1985.tb05668.x.
In relation to the general issue of the long-term effects of epileptic activity on the higher nervous functions, monohemispheric epileptic patients--divided into "lesional" [i.e., with computed tomography (CT) scan-visible lesions] and "nonlesional" (i.e., with CT scan-nonvisible lesions)--were submitted to dichotic verbal and tonal tasks, dichoptic verbal and spatial tasks, and a visual tachistoscopic attentional task. The aim was to investigate whether the typical patterns of hemispheric prevalence, which were observed in normal subjects by using these tests, undergo significant changes in epileptic patients. The findings versus normal subjects seem to demonstrate that (a) in lesional epileptic patients, the prevalence of the hemisphere without macroscopic lesions is a constant rule, whether or not this hemisphere is prevalent in normal subjects; (b) in nonlesional epileptic patients, the patterns are the following: when the epileptic hemisphere is the one that is prevalent in normal subjects, its prevalence is enhanced, whichever the hemisphere; when the epileptic hemisphere is not the hemisphere prevalent in normal subjects, the left one attracts and maintains prevalence, whereas the right one reduces and variously interferes with contralateral prevalence. It is concluded that, with respect to the functions tested, the nature of the epileptic foci seems to influence markedly the interhemispheric prevalence pattern.
关于癫痫活动对高级神经功能的长期影响这一总体问题，将单半球癫痫患者分为“有病变的”（即计算机断层扫描[CT]可见病变）和“无病变的”（即CT扫描无可见病变），并让他们接受双耳言语和音调任务、双眼言语和空间任务以及视觉速示注意力任务。目的是研究通过使用这些测试在正常受试者中观察到的典型半球优势模式在癫痫患者中是否会发生显著变化。与正常受试者相比，研究结果似乎表明：(a) 在有病变的癫痫患者中，无宏观病变的半球占优势是一个恒定规律，无论该半球在正常受试者中是否占优势；(b) 在无病变的癫痫患者中，模式如下：当癫痫发作的半球是正常受试者中占优势的半球时，无论哪个半球，其优势都会增强；当癫痫发作的半球不是正常受试者中占优势的半球时，左半球吸引并保持优势，而右半球则降低并以各种方式干扰对侧半球的优势。得出的结论是，就所测试的功能而言，癫痫病灶的性质似乎明显影响半球间优势模式。
