Department of Internal Medicine-Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Department of Translational Neuroscience, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J Alzheimers Dis. 2024;101(4):1217-1226. doi: 10.3233/JAD-240675.
Apathy is a state of decreased interest, lack of initiative, reduced goal-directed activity and blunted emotional responses. Apathy is one of the most common neuropsychiatric symptoms (NPS) in patients with Alzheimer's disease (AD) and is also relatively omnipresent in individuals with Down syndrome (DS). Little is known about the apathy-like behaviors in rodent models of AD and DS.
This study aimed to characterize apathy-like behaviors with aging in two established DS mouse models: Ts65Dn and Dp16.
A battery of behavioral tests including nestlet shredding, marble burying, nest building, and burrowing were performed to examine apathy-like behaviors. Individual z-scores for each mouse for each test, and a composite z-score of apathy-like behavior were analyzed for all mice from these behavioral tests.
Analysis of individual test results and composite z-score revealed significant apathy-like behaviors in Ts65Dn mice compared to WT controls. In contrast, Dp16 mice did not exhibit significant apathy-like behaviors.
Our study is the first to characterize apathy-like behaviors in mouse models of DS with aging and highlights the difference between Ts65Dn and Dp16 DS model mice regarding apathy-like manifestations with aging.
冷漠是一种兴趣减退、缺乏主动性、目标导向活动减少和情绪反应迟钝的状态。冷漠是阿尔茨海默病（AD）患者最常见的神经精神症状（NPS）之一，在唐氏综合征（DS）患者中也较为普遍。关于 AD 和 DS 啮齿动物模型中的类冷漠行为知之甚少。
本研究旨在研究两种已建立的 DS 小鼠模型：Ts65Dn 和 Dp16 中随年龄增长的类冷漠行为。
使用巢片撕碎、埋丸、筑巢和挖洞等一系列行为测试来检查类冷漠行为。对每个测试的每只老鼠的个体 z 分数进行分析，并对来自这些行为测试的所有老鼠的类冷漠行为综合 z 分数进行分析。
对个体测试结果和综合 z 分数的分析表明，Ts65Dn 小鼠与 WT 对照相比表现出明显的类冷漠行为。相比之下，Dp16 小鼠没有表现出明显的类冷漠行为。
我们的研究首次在具有年龄增长的 DS 小鼠模型中对类冷漠行为进行了特征描述，并突出了 Ts65Dn 和 Dp16 DS 模型小鼠在随年龄增长出现类冷漠表现方面的差异。
