Chang Xiao-Qin, Yue Ren-Song
Endocrinology Department, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China.
Chin J Integr Med. 2025 Jun;31(6):566-576. doi: 10.1007/s11655-024-3917-z. Epub 2024 Sep 20.
The global prevalence of diabetes mellitus (DM) and its complications has been showing an upward trend in the past few decades, posing an increased economic burden to society and a serious threat to human life and health. Therefore, it is urgent to investigate the effectiveness of complementary and alternative therapies for DM and its complications. Luteolin is a kind of polyphenol flavonoid with widely existence in some natural resources, as a safe dietary supplement, it has been widely studied and reported in the treatment of DM and its complications. This review demonstrates the therapeutic potential of luteolin in DM and its complications, and elucidates the action mode of luteolin at the molecular level. It is characterized by anti-inflammatory, antioxidant, and neuroprotective effects. In detail, luteolin can not only improve endothelial function, insulin resistance and β-cell dysfunction, but also inhibit the activities of dipeptidyl peptidase-4 and α-glucosidase. However, due to the low water solubility and oral bioavailability of luteolin, its application in the medical field is limited. Therefore, great importance should be attached to the joint application of luteolin with current advanced science and technology. And more high-quality human clinical studies are needed to clarify the effects of luteolin on DM patients.
在过去几十年中，全球糖尿病（DM）及其并发症的患病率呈上升趋势，给社会带来了日益加重的经济负担，并对人类生命和健康构成严重威胁。因此，迫切需要研究补充和替代疗法对DM及其并发症的有效性。木犀草素是一种广泛存在于某些自然资源中的多酚类黄酮，作为一种安全的膳食补充剂，它在DM及其并发症的治疗方面已得到广泛研究和报道。本综述展示了木犀草素在DM及其并发症中的治疗潜力，并阐明了木犀草素在分子水平上的作用模式。其特点是具有抗炎、抗氧化和神经保护作用。具体而言，木犀草素不仅可以改善内皮功能、胰岛素抵抗和β细胞功能障碍，还能抑制二肽基肽酶-4和α-葡萄糖苷酶的活性。然而，由于木犀草素的水溶性和口服生物利用度较低，其在医学领域的应用受到限制。因此，应高度重视木犀草素与当前先进科学技术的联合应用。并且需要更多高质量的人体临床研究来阐明木犀草素对DM患者的影响。
