Fiedler V B
Eur J Pharmacol. 1985 Aug 15;114(2):189-95. doi: 10.1016/0014-2999(85)90627-2.
The effects of nafazatrom (10 mg/kg, b.i.d., orally for 2 days preoperatively; 10 mg/kg, intraduodenally, 30 min before coronary occlusion) on hemodynamics and arrhythmias were assessed in a group of drug-treated anesthetized pigs and compared with the effects in animals that received the drug vehicle and were treated identically. Infarct size (triphenyl-tetrazolium method) of the left anterior descending coronary artery was 24.4 +/- 2.4% of the left ventricle in nafazatrom-treated hearts after 2 h of occlusion and 26.2 +/- 3.2% in control hearts. Blood pressure, heart rate, left ventricular systolic and end-diastolic pressure, cardiac output and stroke volume were not different between the groups during cardiac insult. There were no differences in the number of premature ventricular contractions, arrhythmia and tachycardia, and ventricular fibrillation. It is concluded that short-term administration of the 5-lipoxygenase inhibitor nafazatrom had no effect on infarction, hemodynamics or arrhythmias in the acutely ischemic porcine myocardium.
在一组经药物治疗的麻醉猪中评估了萘黄酮（术前2天口服，10毫克/千克，每日两次；冠状动脉闭塞前30分钟十二指肠内注射，10毫克/千克）对血流动力学和心律失常的影响，并与接受药物载体且治疗方式相同的动物的影响进行了比较。在闭塞2小时后，用萘黄酮治疗的心脏中，左前降支冠状动脉的梗死面积（三苯基四氮唑法）为左心室的24.4±2.4%，对照心脏中为26.2±3.2%。在心脏损伤期间，两组之间的血压、心率、左心室收缩压和舒张压、心输出量和每搏输出量没有差异。室性早搏、心律失常和心动过速以及心室颤动的数量没有差异。得出的结论是，短期给予5-脂氧合酶抑制剂萘黄酮对急性缺血猪心肌的梗死、血流动力学或心律失常没有影响。
