Hawkey C J, Rampton D S
Gastroenterology. 1985 Nov;89(5):1162-88. doi: 10.1016/0016-5085(85)90225-2.
In 1971 interest in the role of prostaglandins in the gastrointestinal tract was stimulated by the publication of two hypotheses--that aspirin damaged the gastric mucosa by inhibiting prostaglandin synthesis (1) and that cholera toxin caused diarrhea by stimulating it (2). Subsequent research into the gastrointestinal actions of prostaglandins has been considerable and now impinges on clinical practice. This paper reviews the involvement of prostaglandins and related compounds in mucosal protection, in ulcer healing, in diarrhea, and in gastrointestinal inflammation, with particular reference to the growing body of human data.
1971年，两篇假说的发表激发了人们对前列腺素在胃肠道中作用的兴趣。这两篇假说分别是：阿司匹林通过抑制前列腺素合成而损伤胃黏膜（1）；霍乱毒素通过刺激前列腺素而导致腹泻（2）。随后对前列腺素胃肠道作用的研究相当多，且目前已影响到临床实践。本文回顾了前列腺素及相关化合物在黏膜保护、溃疡愈合、腹泻及胃肠道炎症中的作用，尤其参考了越来越多的人体数据。
