豚鼠腹腔巨噬细胞对各种刺激物的不同反应。

The different response of guinea pig peritoneal macrophages to various stimulators.

作者信息

Tanaka M, Shibata Y

出版信息

Gen Pharmacol. 1985;16(4):383-6. doi: 10.1016/0306-3623(85)90200-9.

Abstract

To help clarify the mechanism of prostaglandin (PG) E2 and thromboxane (TX) B2 production by macrophages, the effects of three different stimulators (calcium ionophore A 23187, zymosan A and Actinomyces viscosus) on the release of arachidonic acid and the production of PGE2 and TXB2 from guinea pig macrophages were examined. In the present study, we showed that the produced levels of PGE2 and TXB2 were not dependent on the release of arachidonic acid from the phospholipids.

摘要

为了阐明巨噬细胞产生前列腺素（PG）E2和血栓素（TX）B2的机制，研究了三种不同刺激物（钙离子载体A 23187、酵母聚糖A和粘性放线菌）对豚鼠巨噬细胞花生四烯酸释放以及PGE2和TXB2产生的影响。在本研究中，我们发现PGE2和TXB2的产生水平并不依赖于磷脂中花生四烯酸的释放。